均三唑并噻二唑衍生物的微波合成  

Microwave-enhanced synthesis of 3-substituded -6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

作　　者：白银娟[1,2] 李春圆[1] 赵水侠[1] 陈旭东[1] 赵桂仿[3] 史真[1] 

机构地区：[1]西北大学化学系 [2]西北大学生命科学学院,陕西西安710069 [3]西北大学生命科学学院

出　　处：《化学研究与应用》2008年第3期253-256,共4页Chemical Research and Application

基　　金：陕西省教育厅专项基金(07JK378)资助项目

摘　　要：在无溶剂无催化剂微波辐射下,羧酸与1,3-二氨基硫脲快速反应高产率得到了3-取代基-4-氨基-5-巯基-1,2,4-三唑,该化合物与苯甲酰氯在无溶剂无催化剂微波促进下可以方便地制备化合物3-取代基-6-苯基-1,2,4-三唑[3,4-b][1,3,4]噻二唑。该方法具有反应时间短、环境友好、易于纯化及高产率的优点。产物结构经IR和1HNMR谱进行了表征。3-Substituded-4-amino-5-merecapto-1,2, 4-thiazoles are synthesized rapidly in high yields under the condition of microwave irradiation from carboxylic acids and 1,3 - dianimothiourea without solvent and catalyst. 3 - substituded - 6 - phenyl - 1,2,4 - triazolo[ 3,4, - b ] [ 1,3,4 ] thiadiaxoles are prepared by the reactions of 3 - substituded -4 - amino - 5 - merecapto - 1, 2,4 - triazoles with benzoyl chloride in the absences of solvent and catalyst under microwave - enhanced condition. This method possess such advantages as short reaction time,environmentally benign procedures, easy purification and high yield. The structures of the products are confirmed by IR and ^1 H NMR spectra.

关 键 词：3-取代基-4-氨基-5-巯基-1 2 4-三唑 1 2 4-三唑并[3 4~b]-1 3 4-噻二唑 微波辐射 

分 类 号：O625.4[理学—有机化学]