AMP活化蛋白激酶与脂肪细胞因子  

AMP activated protein kinase and adipocytokines

作　　者：宋君[1] 李宏亮[1] 李光伟[1] 

机构地区：[1]卫生部中口友好医院内分泌代谢病中心,北京100029

出　　处：《国际内分泌代谢杂志》2008年第2期90-92,共3页International Journal of Endocrinology and Metabolism

摘　　要：腺苷酸活化蛋白激酶（AMPK）作为细胞重要的能量感受器，能通过增强分解代谢通路，抑制合成代谢通路，调节代谢和能量平衡。近年来研究显示AMPK同样参与了以瘦素、脂联素及抵抗素等为代表的脂肪细胞因子生理作用的发挥，同时AMPK激活亦可影响脂肪细胞因子的分泌，因此脂肪细胞因子与AMPK相关作用机制的研究将为治疗肥胖、糖尿病和代谢综合征提供新的途径。As a key sensor of cellular energy status, the 5＇ AMP activated protein kinase （AMPK） plays a critical role in energy and metabolism homeostasis. Once activated, AMPK switches off anabolic pathways and switches on catabolic pathways to maintain homeostasis. There is an increasing evidence that AMPK mediates metabolic effects of adipocytokines （ leptin, adiponectin, resistin, etc） and adipocytokines can regulate the activity of AMPK. Furthermore, recent studies have illustrated the interaction between AMPK and adipocytokines and highlighted AMPK as a potential target in the treatment of obesity, diabetes and metabolic syndrome.

关 键 词：AMPK 脂肪细胞因子 脂联素 瘦素 抵抗素 

分 类 号：R587.1[医药卫生—内分泌] R994[医药卫生—内科学]