2型糖尿病易感基因研究的新进展  

Investigation on susceptibility genes of type 2 diabetes

作　　者：杨春香[1] 顾国浩[1] 

机构地区：[1]苏州大学附属第一医院检验科,江苏省临床免疫学重点实验室,215006

出　　处：《国际内分泌代谢杂志》2008年第2期105-108,共4页International Journal of Endocrinology and Metabolism

摘　　要：遗传因素在2型糖尿病（T2DM）的发生和发展中起着重要作用，在大多数病人中，T2DM的发生有着较多基因的改变，每一个基因都起着部分或累积的作用，而环境因素在加速或延缓T2DM发生方面起重要作用。与T2DM及其相关特征（如肥胖、高血压等）的相关基因的发现，有利于发现更好的治疗方法，改善病人的生活质量。本篇综述总结了近来发现的与T2DM发生有关的基因。The genetic factors have an important role in the emergence and the development of type 2 diabetes （T2DM）. In most patients, T2DM resuhs from alterations of various genes, each having a partial and additive effect. Environmental factors play an important role in favoring or delaying the expression of T2DM. Identification of the underlying genetic causes of T2DM and other related traits such as obesity and hypertension will lead to the development of new therapeutic, better the quality of life for T2DM patients. This review focus on our current understanding of the genes involved in susceptibility to T2DM.

关 键 词：2型糖尿病 易感基因 代谢性疾病 TCFTL2 RBP4 

分 类 号：R587.1[医药卫生—内分泌] R563.1[医药卫生—内科学]