脱氢表雄酮硫酸酯治疗老年男性骨质疏松症120例  

Efficacy of dehydroepiandrosterone sulfate in the treatment of osteoporosis in 120 elderly males

作　　者：李蔚[1] 孙宜萍[1] 杨建芬[1] 

机构地区：[1]上海交通大学附属第六人民医院老年科,上海市200233

出　　处：《中国组织工程研究与临床康复》2008年第7期1360-1362,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：上海市科委基金资助项目(034119946)~~

摘　　要：目的:虽然已经有较多的证据提示脱氢表雄酮在骨质代谢中具有良性作用,但还需要更加合理和深入的实验来剔除其衍生激素的生物学效应,以更好地明确脱氢表雄酮对骨质代谢的作用。实验拟进一步验证脱氢表雄酮硫酸酯治疗老年男性骨质疏松症的疗效及安全性。方法:①试验对象:选择2005-10/2006-10本院老年男性门诊及住院原发性骨质疏松症患者120例。诊断标准参照WHO新标准:所测骨密度值低于同性别骨峰值2.5个标准差以上诊断为骨质疏松,从未用过性激素。所有患者随机分为治疗组和对照组,每组60名。②试验方法:治疗组口服脱氢表雄酮硫酸酯100mg、钙尔奇D600mg;对照组口服钙尔奇D600mg。③试验评估:6个月后测定骨密度、血生化指标、骨吸收指标和骨形成指标以及副作用等方面的变化。结果:纳入骨质疏松患者120例,均进入结果分析。①腰椎1、腰椎2～4、股骨颈、股骨上端部位骨密度与治疗前及对照组比较,差异显著(P<0.01)。②治疗后治疗组脱氢表雄酮硫酸酯、胰岛素样生长因子Ⅰ、血清钙、碱性磷酸酶、尿吡啶啉、骨钙素较治疗前及对照组明显提高(P<0.01,P<0.05)。对游离睾丸酮、雌二醇、前列腺特异抗原、谷丙转氨酶、尿素氮、肌酐则无明显影响(P>0.05)。结论:脱氢表雄酮硫酸酯治疗老年男性骨质疏松症有较好疗效且安全可靠,无明显不良反应。AIM： Although there are many evidences showing positive effects of dehydroepiandrosterone sulfate （DHEA-S） in bone metabolism, the reasonable and thorough experiments are still needed to clear the mechanism of DHEA-S on bone metabolism by excluding the biological effect of its derivative hormone. This experiment is to study the efficacy and safety of DHEA-S in treatment of osteoporosis in elderly males. METHODS： ①From October 2005 to October 2006, 120 out- and in-patients with primary osteoporosis who were admitted in Shanghai 6th People＇s Hospital were selected. The diagnosis of primary osteoporosis referred to the new standard from WHO： without the application of sexual hormone, and over 2.5 standard deviation value of bone mineral density lower than the peak value of the same gender subject. All the cases were randomly divided into treatment group and control group （60 cases in every group）.② DHEA-S 100 mg and Caltrate-D 600 mg were orally given to the treatment group; Caltrate-D 600 mg was orally given to the control group.③After 6 months, the bone density, serum biochemical markers, markers of bone resorption and formation as well as side effects were measured. RESULTS： 120 osteoporosis patients entered into analysis.①Compared to the pretreatment and control group, the bone mineral density in lumbar spine 1, lumbar spine 2-4, femoral neck, and upper part of femoral bone were increased significantly in the treatment group （P 〈 0.01）.②The serum concentrations of DHEA-S, insulin-like growth factor-l, calcium, alkaline phosphatase, pyridinoline, and osteocalcin were significantly increased in the treatment group, compared to the pretreatment and control group （P 〈 0.01, P 〈 0.05）. No significant changes in serum free testosterone, estradiol, prostate specific antigen, serum glutamic-oxaloacetic transaminase, blood urea nitrogen and creatinine concentration were found after the treatment （P 〉 0.05）. CONCLUSION： Treatment of osteoporosis in elderly males with

关 键 词：骨质疏松症 脱氢表雄酮硫酸酯 骨密度 组织构建 

分 类 号：R681.4[医药卫生—骨科学]