左旋门冬酰胺酶对急性淋巴细胞性白血病病儿凝血功能的影响及处理对策  

THE EFFECT OF L-ASP ON COAGULATION FUNCTION AND ITS MANAGEMENT IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：陈蕾[1] 张丽萍[1] 程永红[1] 姜淑梅[1] 

机构地区：[1]青岛大学医学院附属医院儿科注射室,山东青岛266003

出　　处：《齐鲁医学杂志》2008年第1期16-17,共2页Medical Journal of Qilu

摘　　要：目的探讨左旋门冬酰胺酶（L-ASP）对急性淋巴细胞性白血病（ALL）病儿凝血功能的影响及处理对策。方法对68例急性淋巴细胞白血病病儿分别于使用L-ASP前后对血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、抗凝血酶（AT）、纤维蛋白原（Fg）及D-二聚体进行检测。结果L-ASP治疗8 d后,所有病儿均出现血浆PT及APTT延长,Fg及AT活性降低、D-二聚体升高,与L-ASP治疗前相比较,有显著性差异（t=3.67-20.44,P〈0.05、0.01）。采取特殊干预措施,可以帮助提高临床治疗效果。结论L-ASP可引起ALL病儿的凝血异常,对其可能引发出血、血栓形成进行干预是有效的。Objective To discuss the effect of L-asparaginase （L-ASP） on coagulation function and its management in children with acute lymphoblastic leukemia （ALL）. Methods Prothrombin time （PT）, activated partial thromhoplastin time （APTT）, antithrombin （AT）, fibrinogen （Fg）, and D-dimer were detected before and during treatment hy LASPin 98 children with ALL. Results Eight days after L-ASP therapy, all the children showed prolonged PT and APTT, decreased activity of Fg and AT, and high level of D-dimer, the parameters above were significantly different as compared with that before therapy （t= 3.67-20.44;P〈0.05,0.01）. Special intervention can improve the treatment. Conclusion LASP may cause abnormal coagula tion function in ALL children, intervention is effective to prevent possible bleeding and throm.

关 键 词：左旋门冬酰胺酶 白血病 淋巴细胞 急性 血液凝固障碍 

分 类 号：R725.5[医药卫生—儿科]