水飞蓟素亚微粒胶囊体内药代动力学研究  

Bioavailability of Silymarin-loaded Nanoparticles

作　　者：张自然[1] 陈满仓[2] 何军[2] 陶建生[1] 奉建芳[2] 

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海医药工业研究院,上海200437

出　　处：《中成药》2008年第3期337-340,共4页Chinese Traditional Patent Medicine

摘　　要：目的:进行了水飞蓟素亚微粒胶囊动物体内的生物利用度研究。方法:采用液质联用法测定Beagle犬血浆中水飞蓟宾浓度,在UltimateTMAQ-C18柱、洗脱剂甲醇-水(50∶50)、流速0.8 mL/min、梯度洗脱,通过ESI离子源、负离子检测,水飞蓟素中3个组分的分离良好。结果:受试制剂和益肝灵片体内药动学均符合一室模型,以原料药为参比制剂,水飞蓟素亚微粒胶囊的相对生物利用度均比片剂高。结论:水飞蓟素亚微粒胶囊具有较高的生物利用度,亚微粒是提高难溶性药物口服生物利用度的良好载体。AIM： To study the oral bioavailability of Silymarin-loaded Nanoparticles （SM-NP）. METHODS： Beagle dogs were employed as experiment animals, Yiganling Tablet and Silymarin Extraction were used as the reference preparations. Three constituents were isolated on UltimateTM AQ-Cls column with mobile phase methanol：water （50： 50） at 0.8 mL/min flow rate using gradient elution and ESI ionic source and negative ion detection. Silybin plasma concentration in rat was determined by LC-M. RESULTS： The pharmacokinetics of the tested preparation and Yiganling Tablet met with one-compartment model. The relative bioavailability of three components of SM-NP were higher than that of Yiganling Tablet. CONCLUSION： The results indicate that SM-NP has better bioavailability than the reference preparation, which confirms that nanoparticles is a good carrier for improving oral bioavailability of poorly-soluble drugs.

关 键 词：水飞蓟素 亚微粒胶囊 生物利用度 犬 

分 类 号：R969.1[医药卫生—药理学]