三七总皂苷纯化和脱色工艺研究  

Studies on process for purification and decolorization of Panax notoginseng saponins

作　　者：李东[1] 黄罗生[2] 平其能[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]中国药科大学中药制剂研究所,南京210038

出　　处：《海峡药学》2008年第1期12-15,共4页Strait Pharmaceutical Journal

摘　　要：目的筛选优化三七总皂苷纯化和脱色的工艺条件及参数。方法采用高效液相色谱法,以三七总皂苷中人参皂苷Rb1、Rg1的纯度和转移率为考察指标,考察了大孔吸附树脂的吸附容量及其它影响纯化效果的因素,以及离子交换树脂的脱色效果。结果通过大孔吸附树脂纯化后总固物中人参皂苷Rb1、Rg1的纯度和为59.2%,其转移率分别为96.1%、95.9%;离子交换树脂脱色后总固物中人参皂苷Rb1、Rg1的纯度和为69.2%,Rb1、Rg1的转移率分别为98.2%、95.2%。结论本文所建立的优化工艺简单可行,可为工业生产提供依据。OBJECTIVE To screen and optimize the purification and decolorization process of Panax notoginseng saponins. METHODS With the purity and transferring rates of ginsenoside Rbl and Rgl regarded as index, the absorptive capacity of macroporous resin was determined, and factors affecting purification and decolorization were optimized. RESULTS The total purity of ginsenoside Rbl and Rgl after purification with macroporous resin was 59. 2%, each transferring rate was 96. 1% and 95.9% . The total purity of ginsenoside Rbl and Rgl after decolorization with ion-exchange resin was 69.2% , each transferring rate was 98.2% and 95.2%. CONCLUSION The purification and decolorization process was simple, practicable and available for industrial production.

关 键 词：人参皂苷RB1 人参皂苷RG1 大孔吸附树脂 离子交换树脂 纯化工艺 

分 类 号：R927.2[医药卫生—药学]