广枣三种粗提物的抗心律失常作用比较  

Comparing the Antiarrhythmia Action of the Extracts from Choerospondias Axillaris (Roxb.) Burtt et Hill

作　　者：杨玉梅[1] 应康[1] 王风华[2] 关辉[1] 覃建民[1] 徐继辉[1] 张长在[1] 白音夫 宋一亭 

机构地区：[1]包头医学院心血管研究室,内蒙古包头014010 [2]内蒙古医学院第三附属医院 [3]内蒙古中蒙医研究所

出　　处：《包头医学院学报》2008年第1期4-7,共4页Journal of Baotou Medical College

基　　金：国家自然科学基金课题(编号30160102)

摘　　要：目的:观察比较广枣中三种不同工艺提取物的抗心律失常作用,为找到一种抗心律失常作用较强的主要化学单体或简单复合物打下基础。方法:(1)乌头碱导致大鼠心律失常;(2)哇巴因导致豚鼠心律失常;(3)结扎冠脉导致大鼠心律失常。结果:样品1、样品2可显著延长乌头碱所致大鼠早搏、室速、室颤、心脏停搏出现时间,使哇巴因所致豚鼠心律失常出现时间延长,明显减少结扎大鼠冠状动脉所导致的室性异位搏动数、推迟心律失常出现时间、缩短室速时程、降低室颤发生率,并呈剂量依赖性。样品3使乌头碱所致大鼠室速、室颤出现时间缩短,使哇巴因所致豚鼠心律失常出现时间缩短,对结扎大鼠冠状动脉所导致的大鼠室性异位搏动数、心律失常出现时间和室速时程均有不同程度的负性影响。结论:样品1、样品2能对抗乌头碱、哇巴因、结扎冠状动脉等所导致的心律失常的发生;而样品3不仅没有对抗作用,还有可能促进心律失常的发生。Objective：To compare the antiarrhythmia actions of 3 kinds of extracts by different methods from Choerospondias Axillaris （ Roxb. ） Burtt et Hill. Methods ： （ 1 ） i. v aeonitine was used to induce arrhythmia in the rats . （2） i. v ouabain was used to induce guinea pig arrhythmia; （ 3 ） Arrhyihmia was induced by ligation of coronary artery in the rats. Results： Compared with the NS group, both sample 1 and sample 2 significantly prolonged the lasting time of ventrieular eetopie beats（VE） ,ventrieular taehyeardia （VT） ,ventricular fibrillation （VF） and heart arrest （HA） induced by using i. v aeonitine in the rats, significantly prolonged the lasting time of arrhythrnias induced by using i. v ouabain in guinea pig, and greatly reduced eetopie beats , delay the beginning time of arrhythmias , shortened the persisting time of ventrieular taehyeardia and decreased frequency of ventrieular fibrillation in the rats of ligation of coronary artery. The actions showed a concentration - dependent tendency. Sample 3 produced opposite effect. Conclusion： Sample 1 and Sample 2 both resisted the occurrence of arrhythmias induced by aeonitine, ouabain and ligation of coronary artery. Sample 3 ,however,promoted the occurrence of arrhythmias.

关 键 词：广枣提取物 乌头碱 哇巴因 结扎冠状动脉 心律失常 

分 类 号：R285.5[医药卫生—中药学] R291.2[医药卫生—中医学]