Micro-CT evaluation and histological analysis of screwbone interface of expansive pedicle screw in osteoporotic sheep  

作　　者：万世勇 雷伟 吴子祥 吕荣 王军 付索超 李波 战策 

机构地区：[1]Department of Orthopedics,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China

出　　处：《Chinese Journal of Traumatology》2008年第2期72-77,共6页中华创伤杂志（英文版）

摘　　要：Objective： To investigate the properties of screwbone interface of expansive pedicle screw （EPS） in osteoporotic sheep by micro-CT and histological observation. Methods： Six female sheep with bilateral ovariectomyinduced osteoporosis were employed in this experiment. After EPS insertion in each femoral condyle, the sheep were randomly divided into two groups： 3 sheep were bred for 3 months （Group A）, while the other 3 were bred for 6 months （Group B）. After the animals being killed, the femoral condyles with EPS were obtained, which were three-dimensionally-imaged and reconstructed by micro-CT. Histological evalu-ation was made thereafter. Results： The trabecular microstructure was denser at the screw-bone interface than in the distant parts in expan-sive section, especially within the spiral marking. In the non- expansive section, however, there was no significant differ-ence between the interface and the distant parts. The regions of interest （ROI） adjacent to EPS were reconstructed and analyzed by micro-CT with the same thresholds. The three-dimensional （3-D） parameters, including tissue min- eral density （TMD）, bone volume fraction （BVF, BV/TV）, bone surface/bone volume （BS/BV） ratio, trabecular thickness （Tb.Th）, and trabecular separation （Tb.Sp）, were sig- nificantly better in expansive sections than non-expan-sive sections （P 〈 0.05）. Histologically, newly-formed bony trabeculae crawled along the expansive fissures and into the center of EPS. The newly-formed bones, as well as the bones at the bone-screw interface, closely contacted with the EPS and constructed four compartments. Conclusions： The findings of the current study, based on micro-CT and histological evaluation, suggest that EPS can significantly provide stabilization in osteoporotic cancellous bones.

关 键 词：Expaasive pedicle screws Osteopomsis Screw-bone inteneaee MICRO-CT Three-dimensional paeters 

分 类 号：R687.3[医药卫生—骨科学]