用SPE法萃取、GC/NPD检测全血中氯氮平药物  

DETERMINATION OF CLOZAPIN DRUG FROM WHOLE BLOOD WITH SPE EXTRACTION AND BY GC/NPD

作　　者：封世珍 

机构地区：[1]公安部第二研究所,北京100038

出　　处：《环境化学》1997年第2期122-124,共3页Environmental Chemistry

摘　　要：本文报道了用固相萃取技术(SPE)富集分离全血中的氯氮平药物,采用气相色谱氮磷检测器(GC/NPD)分析方法.以 SKF_525A为内标物,在1ml全血中加入2.0μg药物,回收率为90.0%,RSD为7.95%.血中最低检出浓度为58ng·ml(^-1)该方法具有简单、快速、准确、灵敏的优点.This paper reports a simple and rapid method for the isolation of Clozapin drug with solid phase extraction (SPE). The column eluate was analyzed by using GC/NPD. SKF525A was used as the internal standard. Recovery studies were performed by adding 2.0μg of drug to 1ml of whole blood samples. The recovery was 90.0%, RSD was 7. 95%, the detection limit is 58ng·ml-1.

关 键 词：氯氮平 固相萃取 GC/NPD 血液检验 

分 类 号：R446.11[医药卫生—诊断学]