扶正消瘕法在大肠癌术后化疗期间调节免疫功能的临床与实验研究  

Clinical and experimental study on the effect of strengthening body resistance and attenuate method on adjusting the immune function of colorectal cancer patients receiving chemotherapy

作　　者：罗政[1] 邹凌云[1] 万会平[1] 

机构地区：[1]江西省人民医院肿瘤科,江西南昌330006

出　　处：《世界肿瘤杂志》2008年第1期16-20,23,共6页Tumour Journal of the World

基　　金：江西省卫生厅中医药科研基金资助课题（编号2005A74）

摘　　要：目的观察扶正减毒汤在大肠癌化疗期间调节免疫功能及减轻毒副作用的效果。方法将60例符合入选标准的大肠癌病人，随机分为治疗组（中药加化疗）和对照组（单纯化疗），对照组仅全身化疗，治疗组在化疗同时服用扶正减毒中药煎剂，每日1剂，两组均观察1周期（21d）。各组病人治疗前及治疗1周期后抽血查T细胞亚群及NK细胞，用流式细胞仪分析结果，实验结束评价疗效，包括药物不良反应、气虚症候、KPS评分及免疫指标。结果①治疗组治疗后NK细胞活性及CD4／CD8比值均有提高，与治疗前相比有显著差异（P〈0．05），而对照组略有降低（P〉0．05），治疗后两组间比较均有显著差异（P〈0．05）；②两组卡氏评分治疗组较治疗前有明显提高，有显著差异（P〈0．05），而对照组略有降低（P〉0．05），治疗后组间卡氏评分比较治疗组高于对照组，有非常显著差异（P〈0．01）；③治疗后，气虚症候积分治疗组明显低于治疗前，有显著差异（P〈0．05），对照组治疗后积分较治疗前升高，差异有显著性（P〈0．05），治疗组明显低于对照组，有显著差异（P〈0．01）；④两组相比较，治疗组在中性粒细胞减少、消化道反应、神经毒性方面明显低于单纯化疗组（P〈0．05），经统计分析有明显差异。在血色素、血小板、肝肾功能毒性方面，两组比较无显著性差异（P〉0．05）。显示中药加化疗组在减少部分毒副反应方面优于单纯化疗组。结论扶正减毒汤与化疗联合治疗大肠癌，能够增强化疗的近期疗效，减少部分毒副反应，有效改善病人气虚症候，提高生活质量，改善病人免疫状态，起到减毒增效作用。Objective To observe the effect of strengthening body resistance and attenuate method on adjusting the immune function of colorectal cancer patients who were receiving chemotherapy, and on reducing the poisonous side effect. Methods 60 colorectal cancer patients were randomly divided into two groups, treatment group （chemotherapy plus traditional Chinese medicine） and control group （chemotherapy only）, respectively. Patients in the control group were given chemotherapy. Treatment group were given Fu Zhen Jian Du once a day and chemotherapy treatment. One week as one cycle, each case was drew blood to check T lymphocyte subgroup and the NK cells with flow cytometry before and after treatment for a cycle. There were appraising curative effects when the experiment finished with drug adverse reaction, deficiency of vital energy symptom, KPS grade and immunoindex. Results There was a significant enhancement of NK cell activity and ratio of CD4/CD8 in treatment group （P〈0.05）.While the result decreased a little in control group, but it had not statistically significance （P〉0.05）.Compared with the indexes of two groups after treatment, both had a difference （P〈0.05）. As to improvement of life quality, the KPS was improved significantly in treatment group （P〈0.05）. While control group was a little decreased, but it had not statistically significance （P〉0.05）. The KPS was higher in treatment group than control group, it had difference （P〈0.01）; Before the treatment, there was no significant difference between two groups in scores of deficiency of vital energy symptom. After the treatment, the score of treatment group was lower obviously （P〈0.05）, but the score of control group was higher than before with statistical difference （P〈0.05）; Compared with the observation of related side effect, the result of the reducing of neutrophilic granulocyte, toxic of nervous system, and response of alimentary canal in treatment group was better than that of control group. The diff

关 键 词：大肠癌 扶正减毒汤 免疫功能 临床观察 

分 类 号：R2-03[医药卫生—中医学] R73-34