青霉素联合红霉素超声雾化吸入治疗儿童急性化脓性扁桃体炎临床疗效观察  

Observation of Clinical Efficacy of Ultrasonic Atomization of Penicillin Combined with Erythromycin in Children with Acute Suppurative Tonsillitis

作　　者：马涛[1] 蒋迎佳[1] 施红[1] 苏海涛[1] 安琪[1] 

机构地区：[1]四川省妇幼保健院急诊科,成都610031

出　　处：《中国循证医学杂志》2008年第3期159-161,共3页Chinese Journal of Evidence-based Medicine

摘　　要：目的探讨青霉素联合红霉素超声雾化吸入治疗儿童急性化脓性扁桃体炎的临床疗效。方法将我院门诊2007年7～12月经临床确诊的70例急性化脓性扁桃体炎患儿以抛硬币法随机分成两组。对照组31例,常规使用青霉素20万单位/(kg·d)静脉滴注治疗,每日两次,连续治疗5天。试验组39例,在对照组治疗的基础上,取红霉素0.1g用生理盐水10ml溶解及注射用水10ml稀释后,做超声雾化吸入,每日两次,每次15min,连续治疗5天。观察两组的疗效,并进行统计学分析。结果试验组治愈率和总有效率分别为61.54%和97.44%,对照组分别为35.48%和77.42%;试验组48h和72h退热率分别为75.36%和89.74%,对照组分别为45.16%和61.29%;试验组48h和72h咽痛改善率分别为76.92%和92.31%,对照组分别为48.39%和70.97%,经秩和或χ2检验,两组间上述各指标差异均有统计学意义(P<0.05),表明试验组治愈率、总有效率、退热时间和咽痛改善情况均明显优于对照组。试验组雾化吸入期间有3例出现轻度恶心、呕吐,经短暂休息后均自行缓解,余无其它不良反应发生。结论青霉素联合红霉素超声雾化吸入治疗小儿急性化脓性扁桃体炎具有疗效较好、起效快、副作用小、安全性好等优点,值得临床应用。Objective To assess the clinical efficacy of ultrasonic atomization of penicillin combined with erythromycin in children with acute suppurative tonsillitis. Methods From July 2007 to December 2007, 70 children with a confirmed diagnosis of acute suppurative tonsillitis were randomized into two groups. Thirty-one patients in the control group received continuous 5-day treatment of routine intravenous drip of penicillin （200 000 units/（kg.d））, twice a day, while 39 patients in the trial group received, in addition to the routine treatment, another 5-day treatment of ultrasonic atomization of 0.1 g erythromycin and 10 ml saline diluted by 10ml sterile water, 15min for each treatment, twice a day. Observation of the clinical efficacy of the two groups and statistical analyses were conducted. Results The cure rate and total effective rate of the trial group were 61.54% and 97.44%, and those of the control group were 35.48% and 77.42%, respectively. The pyretolysis rates at 48 h and 72 h in the trial group were 75.36% and 89.74%, and those in the control group were 45.16% and 61.29%, respectively. The improvement rates of pharyngodynia at 48 h and 72 h in the trial group were 76.92% and 92.31%, and those in the control group were 48.39% and 70.97%, respectively. The results of both rank sum test and chi-square test revealed significant differences between the trial group and the control groups （P〈0.05）, which indicated that the trial group was superior to the control group in terms of cure rate, total effectiveness rate, pyretolysis rate and improvement of pharyngodynia. During ultrasonic atomization, 3 patients experienced mild nausea and vomiting, all of which disappeared after rest. No other adverse reactions were recorded. Conclusions Ultrasonic atomization of penicillin combined with erythromycin for children with acute suppurative tonsillitis is worthy of clinical application due to its better efficacy and safety profile.

关 键 词：儿童 急性化脓性扁桃体炎 红霉素 超声雾化吸入 

分 类 号：R766[医药卫生—耳鼻咽喉科]