中药保肝宁对肝纤维化大鼠血脂及血清瘦素的影响  

Effect of Chinese medicine Baoganning on lipid and serum leptin of liver fibrosis model rats

作　　者：贺松其[1] 文彬[2] 侯丽颖[1] 吕志平[1] 

机构地区：[1]南方医科大学中医药学院,广州510515 [2]解放军四五八医院,广州510602

出　　处：《中华中医药杂志》2008年第4期317-320,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金资助课题(No.30672769);广东省中医药局基金资助课题(No.1050128)

摘　　要：目的:探讨保肝宁抗肝纤维化的作用机制。方法:采用复合因素建立肝纤维化大鼠模型,采用全自动生化分析仪检测总胆同醇(TC)、甘油三酯(TG),采用同位素放射免疫分析法检测血清瘦素(Leptin)水平。观察保肝宁对肝纤维化模型大鼠TC、TG及Leptin水平等各项指标的影响。结果:与正常组组比较,模型组及各药物组血清TC、TG水平明显下降,差异有非常显著性意义(P<0.01);与模型组比较,保肝宁大、中剂量药物组血清TC、TG水平明显升高,差异有非常显著性意义(P均<0.01)。其中,保肝宁大剂量升高TC、TG作用明显明显优于秋水先碱组(P<0.05)。与正常组比较,模型组及各药物组血清Leptin水平均明显升高(P均<0.01)。与模型组比较,各药物组血清Leptin水平明显下降,差异有显著性意义(P<0.01,P<0.05),各药物组降低Leptin作用,差异无显著性意义(P>0.05)。结论:保肝宁可有效防治大鼠肝纤维化,其作用机制可能与通过改善肝功能,调节血脂,降低血清瘦素水平密切相关。Objective： To discuss the mechanism of Baoganning anti-liver fibrosis. Methods： liver fibrosis rat models were established by complex factors. Automatic biochemical analyzer was used to detect TC, TG and RIA isotope analysis was used to detect serum leptin. To observe the influence of Baoganning on TC, TG and leptin level of liver fibrosis model rats. Results： Compared with the normal group, levels of serum TC,TG decreased apparently in model and every drug groups （P〈0.01） . Compared with the model group, levels of serum TC,TG increased apparently in high and medium dose of Baoganning groups （P〈0.01）. The effect of high dose of Baoganning on advancing TC, TG was better than that of colchicin （P〈0.05） . Compared withnormal group, the level of serum leptin of model group and each drug group increased significantly （P〈0.01）.Compared with model group, the level of serum leptin of Baoganning groups decreased significantly （P〈0.01,P〈0.05）. There was no significant differences among every drug group in lowering lepfin （P〉0.05）. Conclusion： Baoganning can effectively prevent and treat liver fibrosis in rats, which may be closely related to the improvement of liver function, adjustment of lipid and reduction of serum leptin.

关 键 词：肝纤维化 模型大鼠 中医药疗法 保肝宁 血脂 瘦素 

分 类 号：R285[医药卫生—中药学]