DNA纳米机器  

DNA Based Nanomachines

作　　者：杨洋[1] 柳华杰[1] 刘冬生[1] 

机构地区：[1]国家纳米科学中心,北京100080

出　　处：《化学进展》2008年第2期197-207,共11页Progress in Chemistry

摘　　要：本文介绍了以DNA为基础的纳米机器的发展现状,强调了核酸作为一种材料在纳米科技领域的重要作用。着重阐述了利用链交换反应或环境因素变化可以驱动DNA二级结构的变化,从而可以构建出形式多样的纳米级核酸分子机器;评价了各类分子机器在效率、寿命和副产物方面的优缺点。在总结前人工作的基础上预测了核酸纳米技术在生命科学、材料科学以及计算科学等诸多方面可能的应用。Other than its biological significance, DNA also plays an important role in materials science and nanotechnology. It has been well established that DNA could serve as an ideal material for ‘bottom-up＇ construction of nano-scale patterns. In this review, recent development of DNA based nanomachines which rely on the responsible secondary structure changes has been summarized and cataloged according to different driven mechanisms. The advantages and shortcomings of each driven mechanism have also been compared. In addition, this review has summarized much efforts in demonstrating working ability of DNA nanomachine, which is critical for the development. Recent progress in using DNA nanomachine to fabricate nanodevices and smart surfaces has also been addressed to illustrate its potential application in materials science and diagnostics in the future.

关 键 词：DNA 自组装 纳米机器 

分 类 号：TB383[一般工业技术—材料科学与工程] Q523[生物学—生物化学]