胰岛素强化治疗对初诊2型糖尿病患者β细胞功能的影响  

Effects of intensive insulin therapy on pancreatic β-cell function in the new cases with type 2 diabetes mellitus

作　　者：蔡可英[1] 张淑贵[1] 焦亮[1] 赵猛[1] 

机构地区：[1]徐州医学院第二附属医院内分泌病科(徐州矿务集团总医院),221006

出　　处：《江苏医药》2008年第3期237-239,共3页Jiangsu Medical Journal

摘　　要：目的观察短期胰岛素强化治疗对伴高血糖的初诊2型糖尿病(T2DM)患者的降糖疗效及其胰岛β细胞功能的影响。方法50例初诊T2DM患者随机分为两组:常规药物治疗组(常规组)和胰岛素强化治疗组(强化组),每组25例。强化组治疗12周后,停用胰岛素改为口服降糖药,继续观察至36周,检测两组患者血糖、糖化血红蛋白(HbA1C)及C肽水平的变化。结果与治疗前相比,治疗4、12、36周,强化组患者的HbA1C较治疗前均降低,血糖在1周时即明显减低(P<0.05),而C肽有不同程度的升高;与常规组相比,强化组患者血糖在1周时较低(P<0.05),而C肽在12、36周明显升高(P<0.05)。结论对伴明显高血糖的初诊2型糖尿病患者,短期胰岛素强化治疗具有快速控制血糖,改善胰岛β细胞功能的作用。Objective To observe the effect of short-term intensive insulin therapy on pancreatic β-cell function in the new cases with type 2 diabetes. Methods Fifty patients were equally randomized into group O treated with oral hypoglycaemic agents and group Ⅰ given intensive insulin therapy. After 12 weeks of intensive insulin therapy, all patients took oral hypoglycaemic agents instead of insulin until week 36. Blood glucose （BG）, plasma C-peptide and glycosylated hemoglobin A1C of week 0, 1, 2, 4, 12, 36 were examined. Results After treatment, BG and HbA1C of group I were decreased obviously, C-peptide was increased. Whereas, as compared to group 0.1 and HbA1C of group Ⅰ were lower, C-peptide was higher. Conclusion To new cases with type 2 diabetes with obvious hyperglycemia, BG can be controlled well and pancreatic β-cell function can be improved by short-term intensive insulin therapy.

关 键 词：2型糖尿病 胰岛素 胰腺Β细胞 

分 类 号：R587[医药卫生—内分泌]