小剂量阿托伐他汀对老年冠心病患者强化降脂治疗的疗效及安全性观察  

Efficacy and Safety of Low Dose Atorvastatin on Decreasing Blood Lipid in Elder Patients with Coronary Heart Diseases

作　　者：舒华[1] 高凤荣[1] 贾素兰[1] 

机构地区：[1]内蒙古自治区医院保健所,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2007年第12期1433-1435,共3页Inner Mongolia Medical Journal

摘　　要：目的:观察老年冠心病患者持续应用小剂量他汀类药物阿托伐他汀钙(立普妥)治疗高脂血症的疗效及安全性。方法:选择65岁以上冠心病、同时符合高脂血症诊断的老年患者60例,均经过阿托伐他汀钙每天10 mg治疗后血脂已达标。随机分为两组,其中治疗组30例,继续服用阿托伐他汀钙每天10 mg治疗,男性22例,女性8例,年龄(71.3±4.6)岁;对照组30例,停用阿托伐他汀钙治疗,男性23例,女性7例,年龄(70.7±4.3)岁,所有患者治疗前及期间均饮食治疗,其他按常规治疗;观察3、12个月后,抽血复查血脂水平,肝、肾功能;每月记录心力衰竭、心绞痛发作等情况,观察调脂效果、肝肾功能、肌溶解等不良反应。结果:治疗组治疗3个月后,TC、TG、LDL-C均有明显下降(P<0.001),其中TC下降7.19%,TG下降12.74%,LDL-C下降12.02%;治疗12个月后治疗组TC、LDL-C仍有明显下降(P<0.001),TG稍下降(P>0.05);而BUN、Cr、GPT均无明显变化(P>0.05)。对照组观察3、12个月后TC、TG LDL-C均有明显升高(P<0.001),对照组中心力衰竭加重、心绞痛发作例数均较治疗组增多,治疗12个月时尤其明显(P<0.05)。所有患者未出现并发症。结论:应用小剂量阿托伐他汀钙(立普妥)治疗老年冠心病的高脂血症患者,能明显降低总胆固醇、低密度脂蛋白,能降低心血管事件发生,无明显肝肾功能损害、肌溶解副作用。Objective：To investigate the efficacy and safety of low dose atorvastatin on hyperlipiemia in elder patients with coronary heart disease（CHD）. Methods： 60 elder patients aged over 65 years were diagnosed in CHD and hyperlipiemia and treated with 10mg/d atrovastatin until the level of blood lipid recovered normally. Above patients were randomly into two groups. In treatment group（n = 30）, 22 males and 8 females aged 71.3±4.6 years received 10mg/d atrovastatin. In control group（n = 30）, 23 males and 7 females aged 70.7±4.3 years took out of atrovastatin. All patients took diet therapy and routine therapy. After 3 months and 12 months, the level of blood lipid, functions of liver and kidney, the occurrence of heart failure and angina pectoris were investigated. The effect of controlling blood lipid , the functions of liver and kidney and adverse reaction including myolysis were observed. Results： After3 months treatment, The level of TC, TG and LDL-C decreased by 7.19 %, 12.74 % and 12.02 % respectively in treatment group（P〈0. 001）. After 12 months treatment, The level of TC and LDL-C still decreased （P〈0. 001 ）, and that of TG insignificantly decreased（P 〉 0. 05）, but the that of BUN, Cr and GPT had no changes（P〉0.05） in treatment group. After 3 months and 12 months, the level of TC, TG and LDL-C increased markly（P〈0. 001） and the,numbers of heart failure and angina pectoris were more in control group（P〈0.05）. There was no complications occurred. Conclusion： Low dose atorvastatin is effective in lowering the level of total cholesterol and low density lipoprotein, reducing the occurrence of cardiovascular events. The medicine has no lesion in liver and kidney function or myolysis.

关 键 词：冠心病 高脂血症 老年 阿托伐汀钙 

分 类 号：R541.4[医药卫生—心血管疾病]