TGF-β_1在子宫内膜异位症与子宫内膜癌中的表达及生物学行为相关性研究  

Expression of TGF-β_1 in human endometriosis and endometrial carcinoma and correlation with biological behavior

作　　者：范佳颖[1] 王卓然[1] 于淼舒[2] 关咏梅[1] 

机构地区：[1]哈尔滨医科大学附属一院妇产科,150001 [2]哈尔滨市242医院

出　　处：《中国优生与遗传杂志》2008年第3期47-48,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究转化生长因子β1(TGF-β1)在子宫内膜异位症、子宫内膜癌中的表达,探讨其表达与子宫内膜异位症发生及子宫内膜异位症和子宫内膜癌生物学行为的相关性。方法采用免疫组织化学方法检测10例子宫内膜异位症在位内膜、异位内膜,10例子宫内膜癌,10例对照组正常子宫内膜TGF-β1的表达。结果TGF-β1在子宫内膜异位症异位内膜组中的表达显著高于子宫内膜异位症在位内膜组及对照组(P<0·05、P<0·05);TGF-β1在子宫内膜癌组中的表达显著高于对照组(P<0·05);TGF-β1在子宫内膜异位症异位内膜组中的表达与子宫内膜癌组中的表达差异无显著性(P>0·05)。结论TGF-β1的异常表达可能与子宫内膜异位症的发生有关;且可能与子宫内膜异位症具有和子宫内膜癌相似的生物学行为有关。Objective： To study the expression of TGF - β1 in human endometriosis and endometrial carcinoma and to explore the correlation between the expression and pathogenesis of human endometriosis and their biological behavior. Methods ： Immunohistochemical SP method was employed to detect the expression of TGF - β1 in 10 specimens of ectopic endometrium and eutopic endometrium of endometriosis, 10 specimens of endometrial carcinoma and 10 specimens of normal endometrium. Results： The expression of TGF - β1 in ectopic endometrium of endometriosis were significantly higher than those of eutopic endometrium and normal endometrium （ P 〈 0.05, P 〈 0. 05 ）, and the expression of TGF - β1 in endometrial carcinoma were significantly higher than those of normal endometrium（ P 〈0. 05）. There was no significant difference between the expression of TGF - β1 in ectopie endometrium of human endometriosis and endometrial carcinoma （ P 〉 0. 05 ）. Conclusion ： The abnormal expression of TGF - β1 might be correlation with the pathogenesis of human endometriosis and the similar biological behavior between human endometriosis and endometrial carcinoma.

关 键 词：子宫内膜异位症 子宫内膜癌 TGF-Β1 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学]