代谢组学与天然药物和中药研究  

Metabonomics in Research of Natural Drugs and Traditional Chinese Medicines

作　　者：刘昌孝[1] 司端运[1] 万仁忠[1] 林艳萍[1] 许妍妍[1] 

机构地区：[1]天津药物研究院药代动力学与药效动力学省部共建国家重点实验室,天津300193

出　　处：《中国天然药物》2008年第2期82-88,共7页

基　　金：国家自然科学基金资助项目(No.30630075);国家支撑计划项目(No.2007BAI41B00)~~

摘　　要：代谢物组学是后基因时代出现的一门新兴"组学"学科,它能用反映整体的代谢物图直接认识生命体的生理和生化状态,因此能提供区别于其他"组学"而来的大量信息。在天然药物和中药研究中,应用代谢组学研究的方法和技术具有广泛的前景,特别是在药物作用机制、靶器官的效应、新药筛选、安全性研究等方面具有理论意义和应用价值。Metabonomics is a new ＂-omics＂ sicience in post-gene time. Metabonomics can be directly applied to understand the physiological and biochemical situation by its ＂metabolome profile＂ as a whole. Therefore it can provide a loft of informa- tion that differed from those came out of other ＂-omics＂. Metabonomics has been used to evaluate test animal models and to evalu- ate disease models, action mechanism of drugs, target response, drug safety and screening of new drugs. Therefore, metabonomics is hopeful to be necessary part on research of natural drugs and traditional Chinese medicines.

关 键 词：代谢物组学 模型研究 药物作用机制 药物安全性 天然药物 中医药 

分 类 号：R28[医药卫生—中药学]