β-Tubulin在正常及妊娠输卵管组织中的表达  

EXPRESSION OF β-TUBULIN IN NORMAL AND PREGNANT OVIDUCT TISSUE

作　　者：熊国平[1] 程秀娟[2] 汪琳[2] 乔建坤[2] 

机构地区：[1]武汉市中心医院妇产科,武汉430014 [2]武汉大学基础医学院组织胚胎学教研室,武汉430071

出　　处：《中国组织化学与细胞化学杂志》2007年第6期706-709,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：湖北省计生委基金(130384)

摘　　要：目的探讨β-tubulin在正常及妊娠输卵管组织中的表达及其临床意义。方法采用免疫组织化学方法和图像分析技术检测正常输卵管及妊娠输卵管组织中β-tubulin的表达,并分别比较增生期与分泌期、分泌期与妊娠输卵管组织中β-tubulin的平均光密度。结果正常输卵管组织β-tubulin的表达分泌期明显强于增生期;妊娠输卵管组织中β-tubulin的表达比分泌期明显减弱。差异均有显著性(P<0.05)。结论β-tubulin在妊娠输卵管组织中的低表达可能是输卵管妊娠的影响因素。Objective To detect the expression of β-tubulin in normal and tubual pregnant tissue and study its clinical significance. Methods The expression of β-tubulin was detected by immunohistochemistry and analysed by image analysis. The average OD value of β-tubulin was compared between the proliferative phase and the secretory phase, between the secretory phase and the oviduct pregnant tissue respectively. Results The positive expres- sion of β-tubulin in the normal human oviduct tissue at the secretory phase was stronger than that at the proliferative phase. While it was lower in tubal pregnant tissue than in the normal oviduct tissue at the secretory phase. The differences were significant （P 〈0. 01 ） . Conclusion The lower expression of β-tubulin in the oviduct pregnant tissue may play an important role in oviduct pregnancy.

关 键 词：Β-微管蛋白 输卵管 妊娠 

分 类 号：R329.3[医药卫生—人体解剖和组织胚胎学]