质子泵抑制剂对快速起搏后心房电生理的影响  

The Electrophysiological Effect of PPI on Atrial After Rapid Pacing

作　　者：程晋芳[1] 王庸晋[1] 

机构地区：[1]长治医学院附属和平医院心血管内科,046000

出　　处：《长治医学院学报》2008年第1期21-24,共4页Journal of Changzhi Medical College

摘　　要：目的:探讨质子泵抑制剂奥美拉唑对心房快速起搏所致家兔心房电重构的影响。方法:24只家兔随机分为4组:生理盐水组、奥美拉唑组、生理盐水+起搏组和奥美拉唑+起搏组。其中生理盐水+起搏组和奥美拉唑+起搏组,分别在静脉注射生理盐水和奥美拉唑后,以最快的心房1∶1起搏频率(500次/min～600次/min)行快速心房起搏3h,分别于起搏前、起搏后0.5h、1h、1.5h、2h、2.5h和3h测定基础刺激周长分别为200ms和150ms时右心房有效不应期(AERP),并分析AERP的频率适应性。结果:单纯注射生理盐水或奥美拉唑,AERP和其频率适应性无显著改变。心房快速起搏使生理盐水+起搏组的AERP200-AERP150较起搏前显著缩短(P<0.05),频率适应性的指标(AERP200-AERP150)/50ms显著缩短(P<0.01)。而奥美拉唑+起搏组的AERP和频率适应性未发生显著变化。结论:奥美拉唑对心房不应期无直接影响,但可有效防止心房快速起搏引起的心房电重构。Objective：AIM To investigate the effects of proton pump inhibitor（PPI）Omeprazole on tachycardia- induced acute atrial electrical remodeling in rabbits. Methods：Twenty- four rabbits were divided into 4 groups randomly： normal saline （NS） group, Omeprazole group, NS ＋ rapid pacing group and Omeprazole ＋ rapid pacing group. The 1 ： 1 rapidest atrial pacing was performed in the latter 2 groups following venous injection of NS and Omeprazole, respectively. Atrial effective refractory period was measured at basic cycle length of 200 and 150 ms before pacing and every 0.5 h after the onset of atrial pacing. Results ： The AERP and the rate adaptation.of AERP had no significant change in normal saline （NS） group, Omeprazole group and Omeprazole ＋ rapid-pacing group. Whereas, the AERP20o and AERP15owere remarkably shortened in NS ＋ rapid pacing group （ P 〈 0.05,vs.basic value）.The rate adaptation of AERP was reversed through the pacing process in NS ＋ rapid pacing group （ P 〈 0.05, vs .basic value）. Conclusion： Omeprazole do not directly modify the AERP,but can attenuate the pacing- induced AERP shortening.

关 键 词：心房颤动 质子泵抑制剂 奥美拉唑 家兔 

分 类 号：R331.38[医药卫生—人体生理学]