糖尿病肾病血浆过氧化脂质及超氧化物歧化酶含量的观察  

Observation on the Content of Plasma Lipoperoxide and Serum Superoxide Dismutase in NIDDM Nephrosis Patients

作　　者：陈新德[1] 刘惠兰[1] 李国刚[1] 易明[1] 段晓峰[1] 李晓忠[1] 

机构地区：[1]北京市复兴医院,北京100038

出　　处：《中国医学科学院学报》1997年第4期305-308,共4页Acta Academiae Medicinae Sinicae

摘　　要：测定了40例非胰岛素依赖型糖尿病（NIDDM）肾病（简称糖尿病肾病）患者和15例正常人（对照组）的血浆过氧化脂质（MDA）和血清超氧化物歧化酶（SOD）含量。结果显示：糖尿病肾病各组患者MDA均显著高于对照组，糖尿病肾病尿毒症组（DKF）明显高于糖尿病肾病早期组（DKE）（P＜0．01），DKF组腹透液中MDA及SOD含量极微。提示：糖尿病肾病各期存在着不同程度脂质过氧化反应，SOD含量对糖尿病肾病肾功能损伤的机理及判断预后有一定临床价值。Objective In order to explore the changes of MDA, SOD in each peried of diabetic nephrosis patients, the contents of MDA and SOD from 40 cases of NIDDM nephrosis patients in various stages and 15 cases of normal persons (control group) were measured. Metbeds By using method of sulpho-barbiamino acid to determine the concentration of serum MDA (the reagents are provided by Juli Biomedical Engineering Institute of Nanjing). By using method of radioimmunization to determine the concentration of SOD (The reagents are provided by Huaqing Bfor loglcal Technic Institute of Beijing), bldri sugar, T-cho, TG, Bun, Ccr, UAE, etc. in serum were simutaneouslly determined. By adopting statistical method to analyse the mean difference in each groups and the interrelation of each data. Results The results show that the content of MDA in each groups exceeds normal control group and the content of MDA of the group of diabetic kidney failure (DKF) exceeds group of diabetic kidney early stage (DKE) obviously (P<0. 01). Only trace of MDA and SOD can be detected in the liquid of peritoneal dialysis in group of DKF. The content of SOD in each groups exceeds normal control group without exception and the content of SOD in group of DKF exceeds that of the group of diabetic kidney function injury stage obviously (P<0. 01). Conclusion Our results suggest that content of SOD might have some clinical value for the diagnosis and prognosis in NIDDM nephrosis and situation of kidney function injury.

关 键 词：糖尿病 肾病 过氧化脂质 超氧化物歧化酶 

分 类 号：R587.2[医药卫生—内分泌] R692.02[医药卫生—内科学]