乙肝疫苗阻断母婴传播失败原因及对策  

Reasons of Failure in Blocking Mother-infant Transmission of HBV by Using Vaccine and Related Strategies

作　　者：于秀良[1] 陈翠华[1] 钟梅[1] 曲玉蓉[1] 许小立[1] 

机构地区：[1]第一军医大学附属南方医院,广州市510515

出　　处：《中华护理杂志》1997年第2期69-71,共3页Chinese Journal of Nursing

基　　金：国家自然科学基金

摘　　要：检测了乙肝表面抗原（HBsAg）阳性32个家庭的母亲．及其经乙肝疫苗全程免疫的子女共66例血清乙型肝炎病毒（HBV）标志物，采用PCR技术及DNA测序方法。对32个家庭中3个乙肝疫苗免疫失败的家庭，7例HBsAg阳性感染者进行HBV的直接序列分析。从分子水平确定HBV母婴传播的可能，从病毒变异的角度探讨乙肝疫苗阻断母婴传播失败的原因。重点对加强传染源的管理及保护易感人群的措施进行讨论。We have detected the serum marker of HBV of 32 mothers whose HBsAg present positive andtheir children whom were given Hepatitis B vaccine immunization throughout duration of their mothers'pregnancy,altogether making up 66 cases. In 3 of these 32 families,Hepatitis B vaccine failed to blocktransmission between mother and infant. Direct nucleotide sequence analysis of HBV were carried out in 7HBsAg positive infected persons. To confirm the possibility of HBV transmission between mother and in-fant on molecular level,we used PCR technique and DNA sequencing method. The reasons of which HBVvaccine failed in blocking transmission were discussed at the point of views of virus variation. Besides,wemake and emphasized discussion on how to tighten up the measurement of controlling the course of infec-tion and protecting susceptible population.

关 键 词：乙型肝炎 病毒 预防 护理 疫苗 

分 类 号：R512.620.5[医药卫生—内科学]