泡利芬和矽肺宁对煤矽肺患者PBL功能亚群影响的研究  

Studies on Effects of Polyphe and “Xi Fei Ning”on the Function Subgroup of Peripheral Blood Lymphocytes in Patients with Coal Silicosis

作　　者：李庆[1,2] 李廷[1,2] 陆文虎[1,2] 祁新兰[1,2] 

机构地区：[1]安徽省淮南矿业学院医学分院微生物学教研室 [2]淮南矿务局职业病防治院

出　　处：《中国工业医学杂志》1997年第5期285-287,共3页Chinese Journal of Industrial Medicine

基　　金：煤炭部安全司泡利芬协作项目资助

摘　　要：为了探讨泡利芬和矽肺宁治疗煤矽肺患者后对外周血淋巴细胞（ＰＢＬ）亚群的影响，选择６１例单纯Ⅰ、Ⅱ期煤矽肺病人，随机分４组，Ａ、Ｂ组分别给予不同剂量的泡利芬口服，Ｃ组给予矽肺宁口服，Ｄ组给予ＶＣ口服，用ＢＡＳ组织化学法检测服药前后（半年）各组ＰＢＬ亚群分布情况。结果经泡利芬治疗后，Ａ、Ｂ二组ＣＤ３较治疗前上升明显（Ｐ＜０．００５），Ｃ组矽肺宁治疗后ＣＤ３上升（Ｐ＜０．０１），Ｄ组ＶＣ治疗后，ＣＤ３较治疗前无明显改变（Ｐ＞０．０５）。提示泡利芬与矽肺宁治疗煤矽肺能提高机体细胞免疫力，且无明显毒副作用，可在煤矽肺的预防及临床治疗中推广应用。Effects of polyphe and“Xi Fei Ning”on the treatment of patients with coal silicosis in their peripheral blood lymphocytes(PBL)subgroup were studied.Sixty one hospitalized patients at stage I and II were selected and divided randomly into four groups.Groups A and B were orally administered with different doses of polyphe,group C with“Xi Fei Ning”,and group D with vitamin C only,respectively.Biotin Avidin system(BAS)histochemical technique was used to detect the distribution of PBL subgroups in various trial groups before and after treatment.Counts of CD 3 increased significantly after polyphe and Xi Fei Ning treatment in groups A,B and C,respectively,as compared with those before treatment (P<0 005 and P<0 01).There was no significant difference in counts of CD 3 before and after vitamin C treatment in group D(P>0 05).Treatment with polyphe and Xi Fei Ning in patients with coal silicosis could improve bodys cellular immunity without obvious toxic and side effects,and should be widely used in the prevention and clinical therapy for coal silicosis.

关 键 词：泡利芬 矽肺宁 煤矽肺 淋巴细胞亚群 

分 类 号：R135.2[医药卫生—劳动卫生]