高原移居和世居者低、高氧通气的反应变化  

Ventilatory response to progressive hypoxia and 100% O 2 breathing in migrators and native highlanders at high altitude.

作　　者：杨生岳[1,2] 冯恩志[1,2] 马子琪[1,2] 詹正嵩[1,2] 

机构地区：[1]中国人民解放军第4医院 [2]中国人民解放军军事医学科学院

出　　处：《中华航空航天医学杂志》1997年第2期98-101,共4页Chinese Journal of Aerospace Medicine

摘　　要：目的探讨高原移居者和世居者对低氧和高氧的通气反应性。方法对５名从平原移居海拔４７５０ｍ２０天～８０天的汉族（Ⅰ组）、１６名从平原移居该高原３年～２０年的汉族（Ⅱ组）和５名当地世居藏族（Ⅲ组）受试者做了呼吸空气、进行性低氧和１００％氧的通气反应测定，以ＶＥ／Ｓａ０２（Ｌｍｉｎ－１）表示通气反应大小。结果呼吸空气时，Ⅰ组ＶＥ／Ｓａ０２值（０．１８±０．１４）明显高于Ⅱ组（０．１３±０．０３）和Ⅲ组（０．１３±０．０３），Ｐ＜０．０５，Ⅱ、Ⅲ组间无显著性差异。进行性低氧１ｍｉｎ、２ｍｉｎ和３ｍｉｎ，Ⅰ组ＶＥ／Ｓａ０２值（分别为０．２０±０．０４、０．２７±０．０４和０．５６±０．０７）明显高于Ⅱ组（０．１４±０．０４、０．２０±０．０４和０．３４±０．０５）和Ⅲ组（０．１３±０．０２、０．１５±０．０３和０．２２±０．０４），Ｐ＜０．０５，Ⅱ、Ⅲ组间第１ｍｉｎ和第２ｍｉｎ无显著性差异，第３ｍｉｎ有显著性差异（Ｐ＜０．０５）。三组吸入１００％氧时，通气量均明显降低。结论平原人移居高原初期，低氧通气反应敏感，而久居和世居高原者则迟钝。三组吸高氧时，通气均被抑制。Objective To study the ventilatory response to hypoxia and hyperoxia in new migrators,resided migrators and native highlanders at high altitude. Methods Ventilatory response to breathing air, progressive hypoxia induced by closed circuit breathing and breathing 100% O 2 were determined in 5 new migrators come from plain to altitude for 20～80 days (group I ), 16 migrators from plain and resided at altitude for 3～20 years (group II) and 5 native highlanders at 4 750 m altitude. Ventilatory response was expressed as minute ventilation to arterial O 2 saturation ratio ( E/SaO 2). Results ①During breathing air, E/SaO 2 in group I (0.18±0.04) was significantly higher ( P <0.01) than that in group II (0.13±0.03) and group III (0.13±0.03), and the E/SaO 2 values of group II and group III were essentially the same. ② E/SaO 2 values of 1st, 2nd,and 3rd minute closed circuit breathing in group I (0.20±0.04, 0.27±0.04, and 0.56±0.07) was significantly higher ( P <0.05 ) than those in group II (0.14±0.04, 0.20±0.04,and 0.34±0.05) and group III (0.13± 0.02, 0.15 ±0.03, and 0.23±0.04), and the difference between values of group II and group III was nonsignificant. ③ During breathing 100% O 2, the E/SaO 2 values were significantly lowered comparing with those during breathing air in all the three groups. Conclusion The results suggested that hypoxia ventilatory response in migrators from plain to altitude for 20～80 days was more sensitive than that in migrators resided for more than 3 years and native highlanders. Ventilation during breathing 100% O 2 was depressed at high altitude in all the subjects.

关 键 词：缺氧症 高浓度氧 通气反应 高海拔 

分 类 号：R852.11[医药卫生—航空、航天与航海医学] R339.54[医药卫生—临床医学]