清开灵注射液对SHP_(sp)出血性中风海马区兴奋性氨基酸含量的影响  

The Effect of Qing Kai Ling Injection on Hippocampal Excitatory Amino Acid in Hemorrhagic Apoplexy of SHR_(sp)

作　　者：蒋玉凤[1] 朱陵群[1] 黄启福[1] 李克玲[1] 邹丽琰[1] 贾旭[1] 严京[1] 李伯光[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中医急症》1997年第5期219-221,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：本研究采用年中易感型自发性高血压大鼠（SHPsp）.观察了清开灵（QKL）注射液对出血性中风海马区兴奋性氨基酸（EAA）含量的影响，以及神经元密度和超微结构的改变。结果显示：QKL能使海马区EAA、谷氨酸、天门冬氨酸明显降低（P＜0．01）；海马CA1区神经元损伤轻,脱失减少,神经元密度计数显著升高（P＜0．01）；超微结构显示，QKL能使出血性中风造成的脑组织变性、坏死、水肿得到改善。上述结果提示，QKL能降低SHPsp出血性中风EAA的释放,起到保护神经细胞的作用。This study adopted strok prone spontaneously hypertensive rats (SHRsp )as subjects to observe the effect of Qing Kai Ling (QKL ) injection on the concentration of excitatory amino acid (EAA ) in hippocampal sector,neuronal density and ultrastructural changes in homorrhagic apoplexy. The exprimental results showed that QKL markedly reduced the concentration of EAA glutamate and aspartate in hippocampal sector (P < 0.01 ). decreased the injury of neuron and markedly increased neuronal density in hippocampal CA1 sector (P<0.01 ). Ultrastructural observation showed that QKL improved the denaturation. necrosis and edema of brain tissue. It was suggested that the protective effect on nerve cells might be associated with a drop of EAA release.

关 键 词：脑出血 中风 海马区 SHRSP EAA 超微结构 

分 类 号：R255.2[医药卫生—中医内科学]