外科患者手术前、后血清ALB、PA及hs—CRP变化的观察  

Perioperative ALB, PA and hs-CRP changes in surgical patients

作　　者：李红霞[1] 张娜[1] 张正[1] 

机构地区：[1]北京大学人民医院检验科,100044

出　　处：《中华普通外科杂志》2008年第3期200-202,共3页Chinese Journal of General Surgery

摘　　要：目的探讨血清白蛋白（albumin，ALB）、前白蛋白（pre-albumin，PA）与超敏C-反应蛋白（hish-sensitivity C—reactive protein，hs-CRP）在不同外科患者手术前、后的变化。方法选取外科手术患者103例，分别测定手术前后血清ALB、PA和hs．CRP水平，并与56例正常对照组进行比较。结果大手术组患者手术前后ALB分别为（43．6±5．1）g／L、（35．8±5．3）g／L、中小手术组患者手术前后ALB分别为（45．0±3．7）g／L，（38．3±5．7）g／L、与正常对照组ALB（46．7±2．9）g／L比较，差异有统计学意义（F=54．07，P〈0．05）。大手术组患者手术前后PA分别为（246±68）mg／L，（160±55）mg／L，中小手术组患者手术前后PA分别为（270±53）mg／L，（207±70）mg／L，低于正常对照组（279±40）mg／L，差异有统计学意义（F=41．18，P〈0．05）。大手术组患者手术前后hs—CRP分别为（5．3±5．1）mg／L，（12．7±4．2）mg／L，中小手术组患者手术前后为（4．5±3．6）mg／L，（11．1±4．3）mg／L，明显高于正常对照组（1．0±0．7）mg／L，差异有统计学意义（F=69．87，P〈0．05）。结论联合检测血清ALB、PA和hs．CRP水平，对各种外科手术患者特别是发生感染的患者有一定的预测和诊断价值。Objective To evaluate the clinical implications of perioperative serum albumin （ALB）, pre-albumin （PA） and high-sensitivity C-reactive protein （hs-CRP） changes in surgical patients. Methods This study included 103 surgical cases undergoing major, moderate or minor surgery respectively. Perioperative serum ALB, PA and hs-CRP levels were measured, Results were compared with 56normalcontrols. Results Pre-andpostoporativeALBwas（43.6±5.1）g/Land（35.8±5.3）g/Lin major surgery patients compared with that of （45. 0 ±3.7） g/L and （38. 3 ±5.7） g/L in moderate or minor surgery patients, both were significantly lower than that of （46. 7 ± 2. 9） g/L in control group （ F = 54. 07, P 〈 0. 05 ） ; Pre- and postoperative PA level was （246± 68 ） mg/L in major surgery patients while that was （ 270 ± 53 ） mg/L and （207 ± 70） mg/L respectively in moderate or minor surgery group, that in both groups were lower than that（279 ±40） mg/L in control group （F = 41.18, P 〈 0. 05 ）, Pre- and postoperative hs- CRP level was （5.3 ±5. 1 ） mg/L and （ 12. 7 ±4. 2） mg/L in major surgery patients compared with that of （ 4. 5 ± 3. 6） mg/L and （ 11.1 ± 4. 3 ） mg/L in moderate or minor surgery patients, again both that in the two groups were much higher than that of （ 1.0± 0. 7 ） mg/L in control group （ F = 69. 87, P 〈 0. 05 ）. Condusions Combined detection of serum ALB, PA and hs-CRP levels is a measure of surgical trauma especially for these patients suffering from postoperative infections.

关 键 词：外科手术 血清白蛋白 前白蛋白 超敏C-反应蛋白 

分 类 号：R686[医药卫生—骨科学]