甲状旁腺高血压因子和甲状旁腺素对细胞钙通道的不同作用  

Different Effect of Parathyroid Hypertensive Factor and Parathyroid Hormone on the Calcium Channel in Cells

作　　者：赵睿珊[1] 王辅才[1] 朱文萍[1] 胡晓东[1] 

机构地区：[1]河北省医学科学院实验医学研究所生化研究室,石家庄050021

出　　处：《生物化学杂志》1997年第3期356-358,共3页

基　　金：国家自然科学基金

摘　　要：In vitro,the effect of dailyzed plasma including parathyroid hypertensive factor (PHF) from SHR and parathyroid hormone (PTH) on 45Ca2+ uptake by vascular tissue was studied in the SD rats tail arteries incubated in the presence of Krebs-Heinsleit (K-H) buffer. The results showed that PHF significant increased 45Ca2+ uptake (3.90±0.56, n=12, P<0.001), but PTH significantly decreased 45Ca2+ uptake (1.08±0.51, n=16, P<0.001) as compared to control (2.20±0. 53, n=12). Increased doses of PTH resulted in decreasing of 45Ca2+uptake. The pressor mechanism of PHF may be due to stimulating calcium channel in smooth muscle cells,increasing 45Ca2+uptake and intracellular calcium in vascular tissues,whereas PTH acts as calcium antagonist,thereby reducing intracellular calcium level, expanding vascular vessels and decreasing blood pressure.In vitro,the effect of dailyzed plasma including parathyroid hypertensive factor (PHF) from SHR and parathyroid hormone (PTH) on 45Ca2+ uptake by vascular tissue was studied in the SD rats tail arteries incubated in the presence of Krebs-Heinsleit (K-H) buffer. The results showed that PHF significant increased 45Ca2+ uptake (3.90±0.56, n=12, P<0.001), but PTH significantly decreased 45Ca2+ uptake (1.08±0.51, n=16, P<0.001) as compared to control (2.20±0. 53, n=12). Increased doses of PTH resulted in decreasing of 45Ca2+uptake. The pressor mechanism of PHF may be due to stimulating calcium channel in smooth muscle cells,increasing 45Ca2+uptake and intracellular calcium in vascular tissues,whereas PTH acts as calcium antagonist,thereby reducing intracellular calcium level, expanding vascular vessels and decreasing blood pressure.

关 键 词：高血压 甲状旁腺 高血压因子 甲状旁腺素 钙通道 

分 类 号：R544.102[医药卫生—心血管疾病]