干扰素联合丙种球蛋白治疗儿童传染性单核细胞增多症疗效分析  

The clinical effectiveness of interferon plus gamma globulin for infectious mononucleosis in children

作　　者：张晓荣[1] 徐佩茹[2] 毛兆娟[1] 彭美娇[1] 

机构地区：[1]暨南大学第三附属医院珠海市人民医院儿科,广东省珠海市519000 [2]新疆医科大学附属第一临床医学院儿科,乌鲁木齐市830000

出　　处：《实用医学杂志》2008年第5期740-742,共3页The Journal of Practical Medicine

摘　　要：目的:探讨3种不同药物组合治疗儿童传染性单核细胞增多症的临床疗效。方法:64例传染性单核细胞增多症患儿分为3组,选用干扰素(ITF组)、干扰素+更昔洛韦(ITF+GCV组)和干扰素+丙种球蛋白(ITF+IVIG组)3种治疗方法,并将治疗效果分为近、远期疗效,将各组的年龄、发病时间、退热时间、咽峡炎时间、平均住院时间、治疗前后白细胞总数和丙氨酸氨基转氨酶的变化、淋巴结肿大的消退时间、治疗费用等数据应用SPSS13.0统计软件进行分析。结果:ITF+IVIG组在退热时间、咽峡炎时间和住院费用方面与ITF组和ITF+GCV组差异有显著性,在住院时间和淋巴结肿大时间上差异不显著。在近期治疗效果上,ITF+IVIG组明显优于其他两组,但在远期疗效、白细胞总数和肝功能转氨酶方面差异无显著性。结论:干扰素+丙种球蛋白可以明显提高儿童传染性单核细胞增多症的近期治疗效果,对远期疗效和总体病程无明显优势。Objective To explore the clinical effectiveness of three different therapies for infectious mononucleosis in childhood. Methods 64 pediatric patients with infectious mononucleosis were divided to receive interferon alone （ITF group）, interferon combined with ganciclovir（ITF ＋ GCV group）, or interferon plus gamma globulin（ITF ＋ IVIG group）. The efficacy was divided into short-term and long-term. Age, time to onset, time to defervescence, duration of isthmitis, average hospital stay, changes in total leukocytes and alanine transaminase （ALT）, time of lymphopathy subsiding, and medical costs were analyzed by the SPSS 13.0. Results There were significant differences in time to defervescence, duration of isthmitis, and medical costs between ITF ＋ IVIG group and ITF group or ITF ＋ GCV group but were nonsignificant differences in average hospital stay and time of lymphopathy subsiding. The short-term efficacy in ITF ＋ IVIG group was superior to that in the other two groups but the long-term efficacy, total leukocytes, and ALT did not differ significantly. Conclusions Interferon plus gamma globulin can obviously enhance the short-term efficacy in children with infectious mononucleosis but has little role in the long-term efficacy and course of the disease.

关 键 词：传染性单核细胞增多症 儿童 干扰素类 丙种球蛋白类 

分 类 号：R725.1[医药卫生—儿科]