手性锌卟啉与氨基酸酯的分子识别性能  

Molecular Recognition of Chiral Zinc Porphyrin with Amino Acid Ester Derivatives

作　　者：王树军[1] 臧娜[2] 阮文娟[2] 朱志昂[2] 

机构地区：[1]廊坊师范学院化学与材料科学学院,河北廊坊065000 [2]南开大学化学系,天津300071

出　　处：《物理化学学报》2008年第3期507-512,共6页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(20271030、20303009);廊坊师范学院科学研究项目博士专项基金(LSZB200602)资助项目

摘　　要：通过紫外-可见光谱滴定法,研究了手性锌卟啉配合物[p-(L-Leu)C2O-TPPZn]与手性氨基酸酯客体在CHCl3中的分子识别行为.实验结果表明,D型氨基酸酯的缔合常数比L型的大,且缔合常数按K(AlaOCH3)<K(ValOCH3)<K(LeuOCH3)<K(PheOCH3)的顺序依次增大.同时,利用圆二色光谱(CD)研究了手性分子识别过程,由CD光谱可知,当不同客体分子配位于主体后则产生作用程度不同的手性环境.此外,结合理论计算采用模拟退火的方法搜索了主客体体系的最低能量构象,发现在主体与客体D,L-PheOCH3之间存在着π-π*相互作用.Molecular recognition of chiral zinc porphyrin [p-（L-Leu）C2O-TPPZn] with amino acid ester derivatives was investigated by UV-Vis spectrophotometric titration and CD spectroscopy. The experimental results suggested that the association constant was KD〉KL for amino acid ester derivatives, and then increased following the order of K（AlaOCH3）〈K（ValOCH3）〈K（LeuOCH3）〈K（PheOCH3）. CD spectroscopy had also been used in order to elucidate the conformation of the host-guest complex, different chiral environments could come into being from CD spectroscopy when different guests coordinated to host. Moreover, the minimum energy conformations of the hostguest system were obtained by simulated annealing, and it was found that there was π-π interaction between host and D,L-PheOCH3.

关 键 词：手性锌卟啉 氨基酸酯 分子识别 CD光谱 模拟退火 

分 类 号：O641.1[理学—物理化学]