2型糖尿病患者尿白蛋白排泄率与血浆纤溶活性的相关性分析  

The association of urinary albumin excretion with fibrinolytic activity in patients with type 2 diabetes

作　　者：王丰松[1] 陈慧[1] 武超英[1] 潘丽[1] 

机构地区：[1]日照市人民医院康复科,山东省日照276800

出　　处：《中国基层医药》2008年第2期196-197,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨2型糖尿病患者24h尿微量白蛋白排泄率（UAE）与血浆纤溶活性改变的关系。方法129例2型糖尿病患者根据UAE分为尿白蛋白正常组、微量白蛋白尿组和大量白蛋白尿组，并以40例健康人为对照组，采用发光底物法测定血浆组织型纤溶酶原激活物（t-PA）和纤溶酶原激活抑制物-1（PAI-1）活性，计算PAI-1／t—PA，并进行UAE、血糖、血脂、血尿素氮、肌酐测定。结果与健康对照组比较，2型糖尿病患者血浆PAI-1活性显著增高，t-PA活性显著降低（P〈0．01）；三组2型糖尿病患者PAI-1／t—PA比值差异有统计学意义（P〈0．05），以大量蛋白尿组患者PAI-1／t-PA比值最高；单因素相关分析发现，AER与PAI-1／t-PA比值呈正相关，其中以微量白蛋白尿组最为明显（r=0．5422，P〈0．001）。结论2型糖尿病患者尿白蛋白排泄率与血浆纤溶活性密切相关。Objective To examine the relationship between UAE and fibrinolytic activity in patients with type 2 diabetes. Methods 129 type 2 diabetic patients recruited and subgrouped by UAE, and the UAE; FBS, lipids,renal function and the activity of t-PA and PAI-1 were conducted in these patients and 40 health people. Re- sults Compared to control group,the activity of PAI-1 was increased and the activity of t-PA decreased dramaticlly in type 2 diabetic group（P 〈 0.05） ;there was significant difference in the ratio of PAI-1 and t-PA between three diabetic groups（ P〈 0.05） ,of three group the ratio of PAI-1 and t-PA was most highest in the patients with macroalbuminuria,and simple correlation analysis showed positive correlation between UAE and the ratio of PAI-1 and t- PA, especially in the patients with microalbuminuria（ r = 0.321, P 〈 0.05 ）. Conclusion The UAE is closely related to fibrinolytic activity in patients type 2 diabetes.

关 键 词：糖尿病 2型 尿白蛋白排泄率 纤溶活性 

分 类 号：R587.1[医药卫生—内分泌]