托特罗定合用坦索罗辛对实验性良性前列腺增生大鼠下尿路功能的影响  

Effects of combination of tolterodine and tamsulosin on BPH induced LUTS in rats

作　　者：商玉萍[1] 段玉光[2] 刘海鹏[2] 

机构地区：[1]安徽省立医院分院药械科,安徽省合肥230031 [2]安徽中医学院安徽省现代中药研究中心药理室

出　　处：《中国基层医药》2008年第2期212-214,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察托特罗定合用坦索罗辛对大鼠实验性良性前列腺增生致下尿路功能紊乱的改善作用。方法健康雄性SD大鼠去势后，丙酸睾丸酮皮下注射制作前列腺增生模型。模型大鼠分别灌胃给予托特罗定（0．4mg／kg），坦索罗辛（0．04mg／kg）或托特罗定＋坦索罗辛[（0．4＋0．04）mg／kg]14d，给药后测定前列腺指数，生理记录仪记录大鼠排尿波后采集排尿时间、排尿间隔时间、排尿点压、排尿压峰值等指标，并记录残余尿量和膀胱容积，观察药物对上述指标的改善作用。结果托特罗定合用坦索罗辛可全面改善良性前列腺增生大鼠的排尿时间、排尿间隔时间、排尿点压和排尿压峰值，能够同时改善大鼠的尿频及排尿困难症状，并减少大鼠残余尿量（P〈0．05或P〈0．01）。两药合用对膀胱容积无明显影响。结论托特罗定合用坦索罗辛在有效减轻良性前列腺增生大鼠下尿路梗阻症状的同时，可有效降低其膀胱兴奋性，未增加良性前列腺增生大鼠的尿潴留危险，为临床治疗同时伴有梗阻和膀胱过度活动症状的前列腺增生患者提供了新的选择。Objective To investigate the efficacy of tolterodine plus tamsulosin in rats with benign prostatic hyperplasia（BPH） induced low urinary tract syndrome（LUTS）. Methods Male rats were castrated,then testosterone propionate were given by subcutaneous injection to induce BPH/LUTS model. Model rats were intragastrically administrated with 0.4mg/kg of tolterodine,0.04mg/kg of tamsulosin or （0.4 ＋ 0.04 ）mg/kg of tolterodine plus tamsulosin for 14 days and urodynamics, residual urine volume and volume of bladder were mearsured. Results Tolterodine plus tamsulosin could simultaneously shorten the micturition duration, prolong the interval duration between micturition, decrease the threshold intravesical pressure at micturition and the max intravesical pressure at micturition significantly. The combined-therapy method could also decrease the residual urine volume to a certein extent and had no obvious influence on enlarging the volume of bladder（P〈0.05 or P〈0.01）. Conclusion Combination treatment with tolterodine and tamsulosin may efficiently ameliorate bladder outlet obstrution and overactive bladder simultaneously, with no extra danger of uroschesis.

关 键 词：前列腺增生 下尿路综合征 托特罗定 坦索罗辛 

分 类 号：R697.3[医药卫生—泌尿科学]