响应曲面法优化植物油沥青中甾醇的提取工艺  

Optimization of Extraction of Sterols in Plant Pitch by Response Surface Methodology

作　　者：卢定强[1] 吴雅霜[1] 陈建辉[2] 段柳[1] 凌岫泉[1] 

机构地区：[1]南京工业大学制药与生命科学学院,材料化学工程国家重点实验室,江苏南京210009 [2]浙江医药股份有限公司,浙江绍兴312500

出　　处：《食品与发酵工业》2008年第2期153-156,共4页Food and Fermentation Industries

基　　金：国家重大基础研究项目(2003CB716000);国家973项目(2003CB716004)

摘　　要：以植物油沥青为原料,采用响应曲面法对影响甾醇提取率的3个主要因素即料固比、提取温度、提取时间进行优化,并建立了甾醇提取率的二次多项回归模型方程。结果表明:优化的提取工艺条件为料固比(mL:g)10.4:1,提取时间2.5 h,提取温度50℃,最佳提取率预测值为77.53%。与实测值基本一致。该提取工艺简单可行,适用于工业化生产。Study was made on extracting sterol from plant oil pitch. Response surface methodology was applied to investigate the effects of the ratios of solution to solid, extraction temperature and time on the extraction yield of sterols. And a mathematical regression model for extraction of sterols was presented. Results showed that the optimal extraction parameters were ：the ratio of solution to solid 10. 4 ： 1, 2.5h, at 50℃. Under those conditions, the predicted extraction yield of sterols was 77.53%, which was very close to real value. This extraction process was simple and feasible with high extraction yield which met the industrial requirements.

关 键 词：植物油沥青 甾醇 响应曲面法 提取 

分 类 号：TQ645.9[化学工程—精细化工]