白藜芦醇纳米乳的制备及其质量评价  

Preparation and Quality Evaluation of Resveratrol Nanoemulsion

作　　者：杨宝平[1] 欧阳五庆[1] 吴旭锦[1] 胡颖[1] 

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100

出　　处：《西北农业学报》2008年第2期20-23,共4页Acta Agriculturae Boreali-occidentalis Sinica

基　　金：国家科技支撑计划(2006BAD04A11);西北农林科技大学校长基金项目(130709)

摘　　要：制备白藜芦醇纳米乳并进行质量评价。通过伪三元相图法优选处方,以聚氧乙烯氢化蓖麻油为表面活性剂,乙醇为助表面活性剂,肉豆蔻酸异丙酯为油相制备白藜芦醇纳米乳,检测纳米乳的形态及粒度分布,并考察其稳定性,紫外分光光度法测其有效成分含量。结果表明,白藜芦醇纳米乳在电子显微镜下呈圆形,平均粒径为16.5±1.5 nm,分布在10-40 nm。白藜芦醇纳米乳保存3个月仍澄清透明,未见分层或絮凝,其稳定温度范围为-4-60℃。纳米乳中白藜芦醇含量为6.184±0.110 mg/L,回收率为95.8%。白藜芦醇纳米乳外观透明、热力学稳定、药物含量高、回收率高,纳米乳基质能明显防止白藜芦醇氧化。Resveratrol nanoemulsion was preparated and its quality was evaluated. The method of preparing the resveratrol nanoemulsion was optimized by studying the pseudoternary phase diagram. RH40, ethanol, IPM and distilled water were selected to prepare resveratrol nanoemulsion. Its shape, particle size, physical stability, and the concentration of resveratrol were tested respectively. The shape of resveratrol nanoemulsion was spherical under TEM, with a mean diameter was 16.5 ± 1.5 nm, distributing between 10～40 nm. It was stable after being deposited under--4～60℃ for three months. The concentration of resveratrol was 6. 184-±0. 110 mg,/L in resveratrol nanoemulsion, and accuracy of assaying was 95.8%. Resveratrol nanoemulsion was transparent and stable. The concentration and the accuracy of assaying of resveratrol in resveratrol nanoemulsion were high. resveratrol was protected from being oxidized by the mechanism of nanoemulsion.

关 键 词：白藜芦醇 纳米乳 质量评价 

分 类 号：R283[医药卫生—中药学]