交感神经活动影响再灌注心律失常  

The influence of sympathetic nervous activity on reperfusion arrhythmia

作　　者：陈凌[1,2,3] 富维骏[1,2,3] 陈思聪[1,2,3] 

机构地区：[1]第二军医大学长海医院心血管内科 [2]第二军医大学基础医学部生理学教研室 [3]第二军医大学长征医院心血管内科

出　　处：《第二军医大学学报》1997年第4期340-341,共2页Academic Journal of Second Military Medical University

摘　　要：目的：观察交感神经活动对再灌注心律失常（ＲＡ）的影响。方法：采用猫在体心肌缺血－再灌注动物模型，同步记录再灌注期肾交感神经放电活动积分值（ＩＲＳＮＡ）和ＲＡ。结果：（１）ＩＲＳＮＡ的增加和ＲＡ发生分别出现在再灌注期的第１～２秒和第４秒。ＲＡ紧随ＩＲＳＮＡ的增加而出现，至再灌注期的第１０～１５秒，ＩＲＳＮＡ的增加达峰值，ＲＡ表现为室性纤维颤动（ＶＦ）；（２）发生ＶＦ组ＩＲＳＮＡ的增加值显著大于发生室性心动过速（ＶＴ）组和室性早搏（ＶＰＢ）组（Ｐ＜０．００１）；ＶＴ组ＩＲＳＮＡ的增加值亦明显大于ＶＰＢ组（Ｐ＜０．０５）。结论：ＲＡ的发生不仅与交感神经活动增强的时相一致，而且其严重程度还与交感神经活动增强程度正相关，提示交感神经活动能促进ＲＡ的发生。Objective: To determine the direct influence of sympathetic nervous activity on reperfusion arrhythmia (RA). Methods: The increment of integral renal sympathetic nervous activity (IRSNA) and ventricular arrhythmia during reperfusion period were recorded in cats in vivo. Results: (1) Increment of IRSNA and occurrence of RA appeared 1～2 s and 4 s after reperfusion, respectively. RA occurred after the enhancement of RSNA closely. The increment of IRSNA peaked 10～15 s after reperfusion, when RA exhibited ventricular fibrillation (VF); (2)The IRSNA increments of animals with VF, ventricular tachycardia (VT), and only ventricular premature beats (VPB) have shown very significant difference between VF group and VT group or VPB group (P<0.001), and significant difference between VT group and VPB group (P<0.05). Conclusion: It suggests that not only the occurrence of RA synchronizes with the enhancement of RSNA, but also the severity of RA has positive correlation with the increment of IRSNA after reperfusion, indicating sympathetic nervous activity plays significant influence on RA.

关 键 词：再灌注 心律失常 交感神经活动 RA 

分 类 号：R541.702[医药卫生—心血管疾病]