血管紧张素Ⅱ受体-1在清醒大鼠血压波动性调节中的作用  

Role of AT 1 receptors in the regulation of blood pressure variability in conscious rats

作　　者：王涤松[1] 尚长浩[1] 张黎明[1] 苏定冯[1] 

机构地区：[1]第二军医大学基础医学部药理学教研室

出　　处：《第二军医大学学报》1997年第4期342-345,共4页Academic Journal of Second Military Medical University

摘　　要：目的：探讨血管紧张素Ⅱ受体－１（ＡＴ１受体）在清醒ＷＫＹ大鼠和自发性高血压大鼠（ＳＨＲ）血压波动性（ＢＰＶ）调节中的作用。方法：应用计算机化清醒自由活动大鼠血流动力学监测技术，分别观察了：（１）静注新型非肽类ＡＴ１受体拮抗剂Ｌｏｓａｒｔａｎ（Ｌｏｓ）；（２）静注神经节阻断剂氯异吲哚铵（Ｃｈｌｏｒ）；（３）静注Ｃｈｌｏｒ和Ｌｏｓ；（４）静滴血管紧张素Ⅱ（ＡＮＧⅡ）及静注Ｃｈｌｏｒ后静滴ＡＮＧⅡ对ＷＫＹ大鼠和ＳＨＲ血压和ＢＰＶ的影响。结果：Ｌｏｓ不影响ＷＫＹ大鼠的血压，但减小其ＢＰＶ，降低ＳＨＲ的血压，但不影响其ＢＰＶ。Ｃｈｌｏｒ降低ＷＫＹ大鼠和ＳＨＲ的血压，增大它们的ＢＰＶ。Ｃｈｌｏｒ＋Ｌｏｓ可降低ＷＫＹ大鼠和ＳＨＲ的血压，但不影响它们的ＢＰＶ。静滴ＡＮＧⅡ升高ＷＫＹ大鼠和ＳＨＲ的血压，增大它们的ＢＰＶ；静注Ｃｈｌｏｒ后再静滴ＡＮＧⅡ，两者血压均维持在各自基础值水平，而ＢＰＶ都极显著增大。结论：交感神经调节的介入掩盖了Ｌｏｓ对ＳＨＲＢＰＶ的影响；交感神经被阻断后，ＡＴ１受体的激活不仅对血压的维持有代偿作用，而且与此时血压发生剧烈波动，即ＢＰＶ增大有关。Objective: To investigate the role of AT 1 receptor in the regulation of blood pressure variability (BPV)in conscious WKY rats and spontaneously hypertensive rats(SHR). Methods: Blood pressure(BP)was measured continuously by computerized system and analyzed for BPV in conscious freely moving rats: (1)after iv Losartan (Los); (2)after iv Chlorisondamine (Chlor); (3) after iv Chlor plus Los; (4) during intravenous infusion of ANGⅡ, and following Chlor during an infusion of ANGⅡ. Results: Los decreased BPV in WKY rats but not in SHR, and decreased BP in SHR but not in WKY rats. Chlor increased BPV and decreased BP in both strains. Chlor plus Los decreased BP, but did not influence BPV. ANGⅡ infusion increased BP and BPV. Following Chlor a continuous infusion of ANGⅡ maintained BP on the basal level whereas greatly increased BPV. Conclusion: The effect of Los on BPV is masked by sympathetic tone in SHR. Activation of AT 1 receptors are not only responsible for maintenance of BP but also for greatly increased BPV in both strains.

关 键 词：血压波动性 受体 血管紧张素 调节 

分 类 号：R331.3[医药卫生—人体生理学] R977.6[医药卫生—基础医学]