猫烫伤休克早期血浆ET-1含量和心肌收缩性的变化  

Dynamic changes of plasma ET 1 content and myocardial contractility during early stage of burn shock

作　　者：何振成[1,2] 陈建国[1,2] 吕萍 侯钢星[1,2] 袁文俊[1,2] 富维骏 

机构地区：[1]第二军医大学基础医学部生理学教研室 [2]第二军医大学长征医院心血管内科

出　　处：《第二军医大学学报》1997年第4期361-362,共2页Academic Journal of Second Military Medical University

基　　金：总后卫生部专项基金

摘　　要：目的：探讨烫伤后血浆内皮素（ＥＴ）含量和心肌收缩性变化的相互关系。方法：利用放射免疫分析法测定猫烫伤早期血浆ＥＴ含量，同时观察烫伤前后ｄｐ／ｄｔｍａｘ和心收缩舒张谐调环（ＣＲＨＬ）的变化。结果：猫烫伤后ｄｐ／ｄｔｍａｘ，ＣＲＨＬ－Ｌｓ和血浆ＥＴ－１含量迅速升高，伤后１０ｍｉｎ达最高。此后持续监测２ｈ，血浆ＥＴ－１仍维持高水平状态，但ｄｐ／ｄｔｍａｘ，ＣＲＨＬ－Ｌｓ却呈大幅度下降。结论：猫烫伤后血浆中出现的高水平ＥＴ会明显抑制心脏活动，加重烫伤休克。Objective: To observe the correlation in changes of plasma ET concentration and myocardial contractility after burn injury. Methods: In cats with Ⅲ degree burn injury of 30% body surface, indicators of cardial function (dp/dt max , CRHL Ls) were measured by radioimmunoassay to observe the changes of plasma ET level and myocardial contractility. Results: After burn injury, dp/dt max , CRHL Ls, as well as plasma ET 1 level increased rapidly and reached their maximum value in 10 min. But in the following 2 h, although plasma ET 1 concentration maintained at high level, dp/dt max and CRHL Ls decreased enormously. Conclusion: The high level of plasma ET after burn injury might inhibit the function of the heart significantly, and aggravate the shock induced by burn injury.

关 键 词：内皮素 心肌收缩 休克 烫伤 

分 类 号：R644.02[医药卫生—外科学]