Association of Single Nucleotide Polymorphisms in Exon 3 of Porcine LMCD1 Gene with Meat Quality and Carcass Traits  

作　　者：WANG Jun DENG Chang-yan XIONG Yuan-zhu ZUO Bo LI Feng-e LEI Ming-gang ZHENG Rong LI Jia-lian JIANG Si-wen 

机构地区：[1]Key Laboratory of Swine Genetics and Breeding, Ministry of Ariculture/Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education/Huazhong Agricultural University, Wuhan 430070, P.R, China [2]The Research Institute of Environmental Science, Wuhan Universi~ of Science and Engineering, Wuhan 430073, P.R.China

出　　处：《Agricultural Sciences in China》2008年第3期370-374,共5页中国农业科学（英文版）

摘　　要：LIM domain proteins are found to be important regulators in cell growth, cell fate determination, cell differentiation, and remodelling of the cell cytoskeleton by their interaction with some structural proteins, kinases, transcriptional regulators, etc. The presence of LIM domains in LMCD1 gene implies it may be involved in skeletal muscle protein-protein interactions. This study was to investigate polymorphisms of LIM and cysteine-rich domain 1 （LMCD1） gene and its effect on meat quality and carcass traits in pig. The polymorphism （G294A） in exon 3 region of porcine LMCD1 gene, which is synonymous mutation, was genotyped in the population of 178 F, pigs of a Large White × Meishan resource family. Statistical results indicated the distribution of allele G （with a A → G mutation） and A （without mutation）. Analysis of variance showed that the polymorphism of LMCD1 gene was associated with variation in several carcass traits of interest for pig breeding. Some carcass traits and meat quality traits are close to significance by association. An analysis of more animals is necessary to analyze the polymorphisms in exon 3 of porcine LMCD1 gene if it was selected as a marker for the pig carcass traits.LIM domain proteins are found to be important regulators in cell growth, cell fate determination, cell differentiation, and remodelling of the cell cytoskeleton by their interaction with some structural proteins, kinases, transcriptional regulators, etc. The presence of LIM domains in LMCD1 gene implies it may be involved in skeletal muscle protein-protein interactions. This study was to investigate polymorphisms of LIM and cysteine-rich domain 1 （LMCD1） gene and its effect on meat quality and carcass traits in pig. The polymorphism （G294A） in exon 3 region of porcine LMCD1 gene, which is synonymous mutation, was genotyped in the population of 178 F, pigs of a Large White × Meishan resource family. Statistical results indicated the distribution of allele G （with a A → G mutation） and A （without mutation）. Analysis of variance showed that the polymorphism of LMCD1 gene was associated with variation in several carcass traits of interest for pig breeding. Some carcass traits and meat quality traits are close to significance by association. An analysis of more animals is necessary to analyze the polymorphisms in exon 3 of porcine LMCD1 gene if it was selected as a marker for the pig carcass traits.

关 键 词：PORCINE LIM and cysteine-rich domain 1 （LMCD1） PCR-SSCP carcass traits meat quality traits 

分 类 号：S858.28[农业科学—临床兽医学]