尾加压素Ⅱ与动脉粥样硬化  

Urotensin Ⅱ and Atherosclerosis

作　　者：陈新胜[1] 张勇刚[1] 

机构地区：[1]汕头大学医学院第一附属医院心内科,广东汕头515041

出　　处：《医学综述》2008年第6期824-826,共3页Medical Recapitulate

摘　　要：尾加压素Ⅱ(UⅡ)是一种在哺乳动物体内新发现的缩血管活性肽,通过激活G蛋白耦联受体(GPR14)而发挥作用。UⅡ能够促进血管平滑肌细胞增殖、诱导心肌成纤维细胞增殖和胶原合成、刺激心肌细胞肥大、促进巨噬细胞向泡沫细胞转化。血浆或组织UⅡ水平在多种心血管疾病中明显升高,提示UⅡ在心血管系统功能障碍和重塑进程中发挥重要作用。UrotensinⅡ（UⅡ） is a vasoconstrictive peptide that exerts its activity by binding to GPR14-the specific receptor of UⅡ.UⅡ can induce vascular smooth muscle cell proliferation,increase collagen synthesis of cardiacfibroblasts and stimulate cardiomyocyte hypertrophy.In addition,UⅡ can also accelerate foam cell formation in macrophages.It is reported that increased UⅡ plasma levels are closely correlated with many cardiovascular diseases,wchih suggested that UⅡshould play an important role in cardiovascular dysfunction and remodeling.

关 键 词：动脉粥样硬化 尾加压素Ⅱ 炎症 

分 类 号：R543.1[医药卫生—心血管疾病]