芍芪多苷的抗炎及其作用机制研究  

Study on the anti-inflammatory effects and the mechanism of Shaoqiduogan

作　　者：赵晓娟[1] 陈根林[1] 王萌[1] 方笋[1] 魏伟[1] 

机构地区：[1]安徽医科大学临床药理研究所,合肥230032

出　　处：《中国临床药理学杂志》2008年第2期139-142,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30572356);安徽省自然科学基金资助项目(050430903);安徽省科技攻关计划基金资助项目(06013133B);安徽省高校首批科技创新团队基金资助项目;高校博士点科研基金资助项目(20060366003);安徽省研究实验基地优秀中青年科研带头人基金资助项目

摘　　要：目的研究芍芪多苷(主要成分:芍药苷与黄芪甲苷)的抗炎作用及其作用机制。方法用棉球植入法制备大鼠棉球肉芽肿模型,分别给予阿司匹林(100mg.kg-1)、芍芪多苷(21.25、42.5、85mg.kg-1)灌胃,每日1次,连续7日后,检测肉芽肿净重。通过连续5日给予阿司匹林(100mg.kg-1)、芍芪多苷(21.25、42.5、85mg.kg-1)灌胃后,观察角叉菜胶诱导大鼠产生的足爪肿胀情况以及检测肿胀足爪中前列腺素E2(PGE2)的含量,探讨芍芪多苷的部分抗炎作用机制。结果芍芪多苷能明显抑制棉球植入法诱导的大鼠肉芽肿的增生及角叉菜胶诱导的大鼠足爪肿胀,并能减少大鼠肿胀足爪中的炎症介质PGE2的含量。结论芍芪多苷有较强的抗炎作用,其作用机制与抑制炎症组织中PGE2的生成有关。Objective To investigate the anti -inflammatory effects and the mechanism of Shaoqiduogan. Methods Inflammatory models of granuloma induced by cotton pellet in rats were randomized into groups treated with aspirin（ 100 mg · kg^-1 ） and Shaoqiduogan（21. 25,42. 5,85 mg·kg^-1 ） . The drugs were intragastrically administered dayly for 7 days. The weight of granuloma was observed. Beside, the edema of the hind paw induced by injecting carrageenan into the hind paw of rats was observed after aspirin（ 100 mg· kg^-1 ） and Shaoqiduogan（ 21.25,42.5, 85 mg ·kg^- 1 ） were administered intragastrically for 5 days. The content of prostaglandin E2 in the swelling hind paw of the rats was determined to observe the mechanism. Results Shaoqiduogan could significantly inhibit the granuloma induced by cotton pellet in rats, the hind paw edema induced by carrageenan in rats, and reduce the content of prostaglandin E2 in the swelling hind paw of rat. Conclusion Shaoqiduogan has significant anti -inflammatory effects. Its mechanism is related to reducing the level of prostaglandin E2.

关 键 词：芍芪多苷 抗炎 前列腺素E2 

分 类 号：R285.5[医药卫生—中药学] R229[医药卫生—中医学]