太原市2006年分离志贺菌菌株的血清分型及耐药性分析  

Serotype and drug resistance of isolated Shigella strains in Taiyuan in 2006

作　　者：刘燕[1] 石洁平 姚宇文 孙樯[1] 张拉弟[1] 王波[1] 

机构地区：[1]山西省太原市疾病预防控制中心,山西太原030001

出　　处：《疾病监测》2008年第2期80-81,共2页Disease Surveillance

摘　　要：目的调查太原市分离的志贺菌菌株的主要血清型和对常用抗菌药物的耐药性。方法对从腹泻患者分离的志贺菌菌株进行血清分型、生化鉴定和药物敏感试验。结果129份腹泻样本分离出阳性菌株40株,其中福氏志贺菌33株,占分离菌株的82.5%,宋内志贺菌7株,占分离总数的17.5%;福氏志贺菌中,4c型21株,占63.6%。福氏志贺菌对萘啶酸100%耐药,对氨苄西林、四环素耐药性均为97%,对头孢噻肟、庆大霉素的药物敏感性均为97%。宋内志贺菌对萘啶酸、四环素、复方新诺明均100%耐药;对阿莫西林、头孢噻肟、环丙沙星的敏感性均为100%。结论2006年太原市志贺菌优势菌型为福氏志贺菌4c型,志贺菌不同血清型对几种常用抗菌药物出现不同程度的耐药性。Objective The study was conducted to investigate the main serotypes and drug resistance to commonly used antibiotics of isolated Shigella strains in Taiyuan. Methods Serotyping, biochemical identification and drug susceptibility tests were performed for the ShigeUa strains isolated from diarrhea patients. Results There were 40 positive strains isolated from 129 diarrhea samples, including 33 strains of ShigeUa flexneri, accounting for 82.5% of all isolates; 7 strains of Shigella sonnei, accounting for 17.5%. 21 strains of ShigeUa flexneri type 4c were found, accounting for 63.6% of all shigella flexneri strains. The ShigeUa flexneri strains had 100% resistance to nalidixic acid, and 97% resistance to ampicillin and tetracycline. By contrast, they had 97% sensitivity to cefotaxime and gentamicin. The Shigella sonnei strains had 100% resistance to nalixidic acid, tetracycline and co- trimoxazole, 100% sensitivity to amoxicillin, cefotaxime and ciprofloxacin. Conclusion The predominant ShigeUa strain was ShigeUa flexneri type 4c in Taiyuan in 2006. Different serotypes of ShigeUa presented varying degrees of resistance to commonly used antibiotics.

关 键 词：志贺菌 血清分型 耐药性 

分 类 号：R446.5[医药卫生—诊断学]