一种新型凝血材料的制备及凝血性能的表征  

The Preparation of Coagulant Material and the Evaluation of Its Coagulant Property

作　　者：胡怡[1] 蔡继业[1] 吴扬哲[1] 王小平[2] 

机构地区：[1]暨南大学化学系 [2]暨南大学第一附属医院,广东广州510632

出　　处：《高分子材料科学与工程》2008年第3期141-144,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(30230350、60578025、30540420311)

摘　　要：将制备的新型凝血材料——透明质酸-Ⅰ型胶原-壳聚糖(HA-COL-CS,简称HCC)复合膜与血小板作用,发现能加强血小板的粘附与聚集,血小板形态发生很大变化,并首次在血小板表面发现颗粒状物质的释放。对比分析不同材料在相同制备条件下引起血小板聚集行为及其表面超微结构的变化,表明由静电自组装法制备的HCC复合膜的凝血效果更佳。A kind of coagulant material composed of hyaluronic acid-type I collagen-chitosan（HCC） was prepared,and the morphological properties of this HCC complex film were characterized.The results indicate that the HCC film can effectively enhance the adhesion,activation and aggregation process of platelets.We also observed the release of microparticles on the membrane of the platelet.By analyzing the aggregation behavior and the ultrastructural changes of platelet induced by the materials,we concluded that the coagulant property of HCC film is better than that of the type I collagen film.

关 键 词：凝血材料 超微结构 凝血性能 血小板微粒 原子力显微镜 

分 类 号：TB39[一般工业技术—材料科学与工程]