壳聚糖/纳米TiO2杂化材料的制备及抗菌性能表征  

Preparation and Anti-Bacterium Properties of Chitosan/TiO_2 Hybrid Films

作　　者：吴峰[1] 蔡继业[2] 

机构地区：[1]怀化学院化学化工系,湖南怀化418008 [2]暨南大学生命科学学院化学系,广州广东510632

出　　处：《高分子材料科学与工程》2008年第3期148-151,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(60278014);广东省自然科学基金资助项目(36704)

摘　　要：制备了壳聚糖/纳米TiO2杂化膜,表征了其抗菌性能,分析了影响TiO2纳米粒子在壳聚糖溶液中分散性的影响因素。FT-IR、AFM分析了杂化膜的结构与形态。表明促进TiO2颗粒良好分散有四个主要因素:(1)表面电荷的重新分布;(2)空间保护作用;(3)化学键的相互作用;(4)超声分散。抗菌实验表明壳聚糖/纳米TiO2杂化膜具有很强的抗菌性能,细菌的形态学变化具有两个显著的特点:(1)细胞内物质渗漏,在细胞周围形成了环状结构;(2)细胞表面囊泡的形成。The complexed films were prepared with different degree of deacetylation chitosan and titanium dioxide nanoparticles.The molecular interactions in chitosan and TiO2 were studied by FT-IR.The microstructure of the films and distribution of nano-particles were investigated by AFM.The results conclude that there are four factors influence the nanoparticles distribution：（1） distributions of surface charges;（2） effects of space protects;（3） interactions of chemical bonds;（4） ultrasonic distribution.The morphology and ultrastructure of the Escherichia coli were observed by AFM.There are two obvious characters：（1） cell contents begin to leak;（2） many blebs are formed on the cell surface.

关 键 词：壳聚糖 二氧化钛 杂化膜 原子力显微镜 抗菌 

分 类 号：TB383[一般工业技术—材料科学与工程]