5-HT_3受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究  

Spectroscopic Analysis on 5-HT_3 Receptor Antagonist Dolasetron Mesylate

作　　者：陈晓红[1] 张倩芝[1] 张卫红[1] 陈建[1] 

机构地区：[1]中山大学测试中心,广东省广州市510275

出　　处：《光散射学报》2008年第1期86-90,共5页The Journal of Light Scattering

摘　　要：甲磺酸多拉司琼是5-羟色胺受体拮抗剂药物,属于肿瘤化放治疗的辅助药物,本文采用傅里叶变换红外光谱仪和激光拉曼光谱仪进行光谱检测,对甲磺酸多拉司琼的拉曼光谱与红外光谱的差异进行分析,对其分子振动光谱与结构特征相关进行分析和探讨,从而为药物合成及质量控制提供了重要的参考价值。Dolasetron mesylate is a 5 - HT3 receptor antagonist which is used on chemotherapy for the prophylaxis of nausea and vomiting. In this paper, the molecular vibration of dolasetron mesylate was detected and measured by FTIR and Raman spectroscopic analysis, the difference between Infrared and Raman characteristic group frequencies of dolasetron mesylate was discussed, and the molecule vibration was assigned and identified to associate characteristic frequencies with its characteristic structure. These experiment results provide more important information for pharmaceutical synthesis and quality control.

关 键 词：甲磺酸多拉司琼 5-羟色胺受体拮抗剂 分子振动光谱 红外光谱 拉曼光谱 

分 类 号：O657.133[理学—分析化学]