海南省健康人群抗脑膜炎奈瑟菌抗体监测分析  

Analysis on Survey for Antibodies Against Neisseria meningitidis in Healthy Population in Hainan Province

作　　者：王少玲[1] 邓海英[1] 黄昌和[1] 吴捷[1] 马焱[1] 

机构地区：[1]海南省疾病预防控制中心,海口570203

出　　处：《中国疫苗和免疫》2008年第1期41-43,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解海南省健康人群抗脑膜炎奈瑟菌（Neisserid meningitides，Nm）感染的抗体水平。方法按《海南省流行性脑脊髓膜炎（流脑）监测方案》的要求，于2006年采集海口市琼山区、东方市、儋州市各年龄组健康人群的静脉血676份，采用酶联免疫吸附试验测定血清中A群和C群Nm多糖抗体（IgG），抗体含量≥2μg／ml为保护性抗体。结果676份血清中，A群IgG抗体≥2μg／ml者420人份，保护率为62．13％；C群IgG抗体≥2μg／ml者195人份，保护率为28．85％。不同年龄组人群Nm多糖抗体水平差异有非常显著的统计学意义（XA^2=72．64，XC^2=56．47；P均〈0．01），其中35～45岁组Nm多糖抗体水平最高。不同地区A群Nm多糖抗体保护率差异有非常显著的统计学意义（X^2=54．76，P〈0．01）。但c群Nm多糖抗体保护率差异无显著的统计学意义（X^2=3．92，P〉0．05）。结论海南省部分地区健康人群A群NmIgG抗体处于中等水平，C群NmIgG抗体处于较低水平。建议加强脑膜炎球菌多糖疫苗（menignococcal polysaccharide vaccine，MPV）的接种，同时推广使用A＋C群MPV。Objective To survey antibodies against neisseria meningitidis in healthy population in Hainan Province. Methods 676 blood samples of healthy population were collected into different groups of age from Qiongshan in Haikou,Dongfang and Danzhou in 2006 according to the requirements of epidemic cerebrospinal meningitis survey plan of Hainan Province. The enzyme linked immunosorbent assay（ELISA）was used to detect meningococcal polysaccharide antibodies （IgG）against group A and C. Protective antibodies≥2/μg/mL. Results The antibody against group A of 420 samples ≥2/μg/mL, protective rate was 62.13%（420/676）. The antibody against group C of 195 samples ≥2μg/mL. Protective rate was 28.85%（195/676）. There was a significant difference in age groups （P 〈0.01）. The group of 35 -45 years old had the highest antibodies. There was a significant difference of protective rate against group A in different areas （P〈 0.01）. The protective rate in Qiongshan was highest,and Danzhou was lowest. However there was no significant difference of protective rate against group C. Conclusion The antibody IgG against group A of epidemic cerebrospinal meningitis of healthy people in the areas of Hainan Province was in middle level. But the antibody IgG against group C was low. The vaccine against epidemic cerebrospinal meningitis should be immunized strongly,and the vaccine against group A＋C should be popularized.

关 键 词：流行性脑脊髓膜炎 抗体 监测 

分 类 号：R512.3[医药卫生—内科学]