新诊断2型糖尿病血脂谱特点及低密度脂蛋白颗粒直径的影响因素分析  

Dyslipidemia feature of newly diagnosed type 2 diabetes and influential factors of low density lipoprotein size

作　　者：任利民[1] 高鑫[1] 林寰东[1] 高键[2] 吴丹[1] 

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032 [2]复旦大学附属中山医院营养科,上海200032

出　　处：《复旦学报（医学版）》2008年第2期282-285,共4页Fudan University Journal of Medical Sciences

基　　金：上海市科委重大项目(04dz19501-1)

摘　　要：目的探讨新诊断2型糖尿病患者的血脂谱及低密度脂蛋白(low density lipoprotein,LDL)颗粒直径的特点,分析LDL颗粒直径的影响因素。方法对240例新诊断2型糖尿病患者和60例非糖尿病个体进行体重指数、腰臀比、血糖、血脂谱的比较,以多元逐步回归模型分析LDL颗粒直径的影响因素。结果新诊断糖尿病组血脂异常者171例,发生率为71.3%,新诊断糖尿病组与对照组比较,三酰甘油升高,HDL-c降低,LDL-c升高,LDL颗粒直径减小,差别均存在统计学意义(P<0.05),LDL颗粒直径与体重指数,HDL-c正相关,与舒张压,空腹血糖负相关(P<0.05)。结论新诊断2型糖尿病患者有较高的血脂异常发生率,其血脂异常的特点为高三酰甘油,低密度脂蛋白胆固醇升高,高密度脂蛋白胆固醇降低和LDL颗粒直径缩小,以小而密表型为主,LDL颗粒直径的缩小与舒张压、空腹血糖和HDL-c有关。Objective To investigate the dyslipidemia features of newly diagnosed type 2 diabetes and detect the influential factors of（low density lipoprotein,LDL）size.Methods We compared body mass index,waist-to-hipratio（WHR）,fasting blood glucose（FBG）and lipid profile between 240 newly diagnosed type 2 diabetics and 60 non-diabetics.Multiple linear stepwise regression analysis was applied to detect the influential factors of LDL size.Results The prevalence of dyslipidemia in the diabetes group was 71.3%（China standard）.Diabetic group had higher triglyceride,LDL-c and lower HDL-c levels compared to non-diabetics（P〈0.05）,the LDL size was significantly smaller than non-diabetics（P〈0.05）,Multiple linear stepwise regression analysis showed that LDL size was negatively correlated with HDL-c but positively correlated with diastolic pressure and FBG.Conclusions Newly diagnosed type 2 diabetes had high prevalence of dyslipidemia,the LDL size was associated with diastolic pressure,FBG and HDL-c.

关 键 词：2型糖尿病 小而密低密度脂蛋白 LDL颗粒直径 

分 类 号：R587.1[医药卫生—内分泌]