昆明山海棠对育龄妇女卵巢功能的影响  

Influence of Tripterygium Hypoglaucum Hutch on Function of Ovary in Reproductive Age Women

作　　者：徐成康[1] 赵云荷[1] 

机构地区：[1]中山大学附属第一医院妇产科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2008年第2期202-205,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科委攻关基金项目(C306602)

摘　　要：【目的】通过观察昆明山海棠对育龄妇女卵巢功能的影响,初步了解影响的规律,探讨此药用于治疗雌激素依赖性疾病的可行性。【方法】将我院风湿科门诊无生育要求的类风湿关节炎患者按随机原则,选择一个研究组和一个对照组,每组50例。研究组给予昆明山海棠,对照组不给任何药物。分别于用药3、6个月结束及停药后3、6个月结束检查卵巢功能,包括月经表现、外周血生殖内分泌激素(雌二醇E2,孕酮P等)、及子宫内膜厚度。统计学方法采用Kruskal-Wallis分析。【结果】①月经的变化:研究组服药第3个月经周期延长有33例(66%),闭经1例(2%);第6个月经周期延长有5例(10%),闭经45例(90%)。对照组未出现月经改变。②外周血性激素水平的变化:研究组治疗3个月后,E2、P水平均下降,至6个月时下降更为显著(治疗前后相比P<0.01),停药3个月后,E2、P水平开始恢复,但未达治疗前水平,6个月时基本恢复到治疗前水平;治疗3个月后FSH、LH显著升高,至6个月时上升更为显著(治疗前后相比P<0.01),停药3个月后,FSH、LH也开始恢复,6个月时基本恢复到治疗前水平;治疗后及停药后PRL和T无明显变化(P>0.05)。对照组治疗及停药后,PRL、FSH、LH、E2、P、T水平无明显变化(P>0.05)。③B超检查所见:研究组治疗3个月后,内膜开始变薄,停药后3个月后开始逐渐恢复到用药前大小,对照组无明显变化(P>0.05)。【结论】昆明山海棠用药时间越长,引起闭经的机会越大。药物通过直接作用抑制卵泡的发育,而不是通过降低促性腺激素水平来抑制卵泡发育。短期应用具有一定可恢复性。[Objective ] To investigate the feasibility of therapy of estrogen dependent disease with tripterygium hypoglaucum hutch by observing influence of tripterygium hypoglaucum hutch on the function of ovary in reproductive age women. [Method ] One study group and one control group were chosen from reproductive age women with rheumatoid arthritis according to randomized design, each group has 50 cases. Study group were orally administrated with tripterygium hypoglaucum hutch, control group were vacant. Ovary function marks （include menses change, sex hormone level in periphery blood, endometrium thickness） were detected by the end of 3 and 6 months after therapy, then stop the administration and follow the study group, the same ovary function marks was detected by the end of 3 and 6 months after drug withdrawal. To analyze the result with Kruskal-Wallis Statistic methods. [Result] （1）change of menses： 33 cases appeared decrease of menstrual and one case appeared amenorrhea in study group by the end of third month administration, by the end of sixth month, there were 5 cases of menstrual blood volume decrease and 45 cases of amenorrhea. There was no change of menses in vacant control group. （2） change of sex hormone level in periphery blood： In the study group, the level of E2 and P dropped but the level of FSH and LH stepped up from third month of treatment and recovered from the third month after drug withdrawal, there were no change in the level of PRL and T. In control group, there were no change of sex hormone level in periphery blood. （3） B-scan ultrasound： endometrium began thin by the end of sixth month of treatment but recovered gradually from third month after drug withdrawal in study group, there was no significant change in control group. [Conclusion] The longer tripterygium hypoglaucum hutch was given, the higher probability of amenorrhea was shown. The results implied that the drug suppress the ovary follicle development through direct action on ovary other than indirect action on th

关 键 词：昆明山海棠 卵巢功能 育龄妇女 

分 类 号：R714.21[医药卫生—妇产科学]