Design,synthesis and antifungal activities in vitro of novel tetralin compounds  

作　　者：Hui Tang You Jun Zhou Yao Wu Li Jia Guo Lv Can Hui Zheng Jun Chen Ju Zhu 

机构地区：[1]Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

出　　处：《Chinese Chemical Letters》2008年第3期264-268,共5页中国化学快报（英文版）

摘　　要：Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhihitars of fungi.Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhihitars of fungi.

关 键 词：ANTIFUNGAL Chiral tetralins Lanosterol 14α-demethylase DESIGN SYNTHESIS 

分 类 号：TQ46[化学工程—制药化工]