净肝祛脂汤治疗非酒精性脂肪肝的临床研究  

A clinical study on Jingganquzhi decoction(净肝祛脂汤) in treating non-alcoholic fatty liver

作　　者：林雪[1] 尚玉红[1] 周斌[1] 

机构地区：[1]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《中国中西医结合急救杂志》2008年第2期98-100,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：新疆自治区青年科技人才基金资助项目(2001Y20)

摘　　要：目的观察净肝祛脂汤治疗非酒精性脂肪肝患者的临床疗效。方法将80例非酒精性脂肪肝患者随机分为两组,治疗组予自拟中药方剂净肝祛脂汤口服,对照组予东宝肝泰口服,疗程均为3个月。观察两组肝功能、血脂指标及肝脏B超的变化。结果两组治疗后肝功能指标丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(γ-GGT)及血脂指标总胆固醇(TC)、三酰甘油(TG)均较治疗前明显下降,高密度脂蛋白胆固醇(HDL-C)明显升高,差异有统计学意义(P均<0.01);与对照组比较,治疗组治疗后肝功能中各项血清酶指标及血脂指标TC、TG下降显著,HDL-C上升明显,差异有统计学意义(P均<0.05)。肝脏B超显示,治疗组治疗后脂肪肝清除率明显高于对照组(40.0%比20.0%,P<0.05);且治疗组痊愈率及总有效率也明显高于对照组(痊愈率:25.0%比10.0%,总有效率85.0%比60.0%,P均<0.05)。结论净肝祛脂汤治疗非酒精性脂肪肝疗效显著,安全性良好。Objective To observe the therapeutic effect of Jingganquzhi decoction （JQ,净肝祛脂汤） in treating non-alcoholic fatty liver. Methods Eighty patients with non-alcoholic fatty liver were randomly divided into treatment group to receive JQ and control group to receive Dongbaogantai （DG,东宝肝素） orally for 3 months. The changes of liver function, blood lipids, B ultrasonic examination were observed. Results After the treatment, the liver function criteria： alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase （ALP）, γ-glutamyltransferase （7-GGT） and blood lipids of triglycerides （TG）, total cholesterol （TC） were lower than those before the treatment, while the high-density lipoprotein cholesterol （HDL-C） was higher than that before the treatment in both groups （all P〈0.01）. The liver function criteria of ALT, AST, ALP and blood lipids of TC and TG of the treatment group were significantly decreased compared with those of the control group, and HDL-C was increased compared with that of the control group （all P〈0.05）, the improvement of B ultrasonic examination was significantly better in treatment group than that in the control group （40.0% vs. 20.0%, P〈0.05）. The healing rate and total therapeutic effective rate in the treatment group was obviously better than that in the control group （healing rate： 25.0% vs. 10.0%, total therapeutic effective rate.. 85.0% vs. 60.0%, both P〈0.05）. Conclusion JQ is obviously effective in treating non-alcoholic fatty liver with favorable safety.

关 键 词：净肝祛脂汤 非酒精性脂肪肝 临床研究 

分 类 号：R259[医药卫生—中西医结合]