山西省出生缺陷高发区饮用水中化学元素异常特征分析  

Analysis of element content in water in the high prevalence areas of Shanxi Province

作　　者：何艳微[1] 张科利[1] 王劲峰[2] 郑晓瑛[3] 张廷 

机构地区：[1]北京师范大学地理学与遥感科学学院,北京100875 [2]中国科学院地理科学与资源研究所 [3]北京大学人口研究所 [4]北京儿童医学研究所

出　　处：《中国妇幼保健》2008年第9期1246-1248,共3页Maternal and Child Health Care of China

基　　金：国家重点基础研究发展规划项目(2001CB510305)

摘　　要：目的:寻找山西省出生缺陷高发区饮用水中含量异常的化学元素,为出生缺陷的干预及治疗提供理论依据。方法:在出生缺陷高、低发区分别采集当地居民的生活饮用水,采用ICP-电感耦合等离子发射光谱法对16种元素进行含量测定。结果:与对照区水样相比,出生缺陷高发区水样中As、Mo、Sr、Pb、V、Na含量显著偏低,Sn、Se、Zn、Ni、Ca、Cu、K含量显著偏高;以病情为因变量、16种元素含量为自变量经逐步回归分析,Mo、Mg、Sr、Ca、As、Sn、V等进入方程。结论:Mo、Sr、As、V在水体中的含量异常可能是出生缺陷发生的重要因素,Pb、Na等偏低与Se、Zn、Ni、Fe、Cu、Al、K等偏高可能与Mo、Sr、As、V、Ca、Sn等元素共同起到协同致病的作用。Objective： To explore elemems of abnormal content in deep - well water in the high prevalence areas of birth defects in Shanxi Province in order to afford theory evidence for preventing and curing diseases. Methods： Some water was sampled from the high and the low prevalence areas of birth defects respectively, then the content of 16 kinds of elements were measured with ICP machine. Last, the data were analyzed statically with regression and nonparametrle tests. Results： The contents of As, Mo, St, Pb, V, Na were signlfieandy low in water coming from the high prevalence areas, but Sn, SO, Zn, Ni, Ca, Cu, K had signifieandy high content, the result of stepwise linear regression was that Mo, Mg, Sr, Ca, As, Sn, V selected into the equation. Conclusion： The low concentration of Mo, St, As, V and high content of Ca and Sn in water might have relationship to birth defects, besides, it is possible that there is synergistic effects between Pb, Na, SO, Zn, Ni, Fe, Cu, Al, K and the above elements for the occurrence of birth defects.

关 键 词：出生缺陷 微量元素 协同作用 山西省 

分 类 号：R123.1[医药卫生—环境卫生学]