烟碱对大鼠心电图的影响  

The Influence of Nicotine on Rat ECG

作　　者：刘鼎阔[1] 籍永录 丁增伟[3] 裴志花[1] 张延林[1] 焦石[1] 

机构地区：[1]吉林农业大学动物科技学院,吉林长春130118 [2]吉林省通化市公园管理处,吉林通化134001 [3]吉林农业大学农学院,吉林长春130118

出　　处：《动物医学进展》2008年第3期50-53,共4页Progress In Veterinary Medicine

摘　　要：烟碱对心率的作用具有阶段性,初期引起心率短暂性减弱,紧接着发生瞬时增加。为进一步确定烟碱对大鼠心脏的作用,对描记烟碱作用后大鼠心电图进行分析,发现烟碱能引起大鼠心电图显示较长的QT间期,增加了PR间期及T波面积,与肾上腺素或去甲肾上腺素引起的QT间期延长相似,且能被M受体阻断剂阿托品所阻断,说明烟碱能够诱导局部释放乙酰胆碱或者作用于部分副交感神经控制的毒蕈碱受体。The nicotine has a stage function to the heart rate, first causing a brief decrease followed by a transient increase. In order to verify nicotine effect to heart of rat, analyzing the （electrograph） ECG at the nicotine to rat, it was discovered that nicotine can cause a longer QT interval and increase the PR interval and T-wave area,with the function likeness of adrenaline or noradrenalin, was blocked furthermore by M-subunit antagonist atropine. Based on these results, it was demonstrated that nicotine can induce to release acetylcholine locally or act on muscarinic cholinoreceptor controlled by parasympathetic nerve.

关 键 词：烟碱 心电图 QT间期 去甲肾上腺素 

分 类 号：S852.21[农业科学—基础兽医学]